GC/MS and the chromatographic challenge

P.A. Leclercq, C.A.M.G. Cramers

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Samenvatting

Application of high pressure drop (narrow-bore, vacuum-outlet) columns shortens analysis times and lowers detection limits at least in proportion to the reduced column diameter. In the scanning mode in GC/MS, only quadrupole instruments can meet this challenge for columns (with 105 plates I with diameters down to 30-50 mum. For still faster separations on even smaller bore columns only simultaneous ion collecting mass spectrometers are suited (e.g. time-of-flight instruments, magnetic mass spectrometers with "electronic" photoplates). The hitherto experienced bottleneck, the transport of vast amounts of mass spectral data per time unit to mass storage devices, can nowadays be overcome by storing all data in ever cheaper and ever expanding computer memory. Theoretically, there is no limit in gas chromatographic separation speed. One might speculate on GC/MS on the MS/MS time scale of mus. Current research indicates, however, that 10 mum i.d. columns are the limit in practice.
Originele taal-2Engels
TitelNinth International Symposium on Capillary Chromatography, Monterey, California, USA, May 16-19, 1988
RedacteurenP. Sandra
Plaats van productieHeidelberg
UitgeverijHuethig
Pagina's739-746
StatusGepubliceerd - 1988
Evenement9th International Symposium on Capillary Chromatography - Conference Center, Monterey, Verenigde Staten van Amerika
Duur: 16 mei 198819 mei 1988

Congres

Congres9th International Symposium on Capillary Chromatography
Land/RegioVerenigde Staten van Amerika
StadMonterey
Periode16/05/8819/05/88
AnderNinth Eighth International Symposium on Capillary ChromatographyMonterey, California, USA, May 16-19,1988

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