Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

Jacobus F.A. Jansen; Albert P. Aldenkamp; H.J.M. Majoie; Rianne P. Reijs; Marc C.T.F.M. de Krom; Paul A.M. Hofman; M.E. Kooi; Klaas Nicolay; Walter H. Backes

doi:10.1016/j.yebeh.2006.05.004

Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

Jacobus F.A. Jansen (Corresponding author), Albert P. Aldenkamp, H.J.M. Majoie, Rianne P. Reijs, Marc C.T.F.M. de Krom, Paul A.M. Hofman, M.E. Kooi, Klaas Nicolay, Walter H. Backes

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

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Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.

Originele taal-2	Engels
Pagina's (van-tot)	181-185
Aantal pagina's	5
Tijdschrift	Epilepsy and Behavior
Volume	9
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.yebeh.2006.05.004
Status	Gepubliceerd - 1 aug. 2006

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title = "Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy",

abstract = "Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.",

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AU - Jansen, Jacobus F.A.

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AU - Majoie, H.J.M.

AU - Reijs, Rianne P.

AU - de Krom, Marc C.T.F.M.

AU - Hofman, Paul A.M.

AU - Kooi, M.E.

AU - Nicolay, Klaas

AU - Backes, Walter H.

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AB - Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.

KW - Cognition

KW - Epilepsy

KW - Functional magnetic resonance imaging

KW - Language

KW - Neuropsychology

KW - Topiramate

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Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

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