Focal application of accelerated iTBS results in global changes in graph measures

Deborah C.W. Klooster (Corresponding author), Suzanne L. Franklin, René M.H. Besseling, Jaap F.A. Jansen, Karen Caeyenberghs, Romain Duprat, Albert P. Aldenkamp, Anton J.A. de Louw, Paul A.J.M. Boon, Chris Baeken

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Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.

TaalEngels
Pagina's432-450
TijdschriftHuman Brain Mapping
Volume40
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 1 feb 2019

Vingerafdruk

Brain
Cluster Analysis
Biomarkers
Magnetic Resonance Imaging
Research

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    Klooster, D. C. W., Franklin, S. L., Besseling, R. M. H., Jansen, J. F. A., Caeyenberghs, K., Duprat, R., ... Baeken, C. (2019). Focal application of accelerated iTBS results in global changes in graph measures. Human Brain Mapping, 40(2), 432-450. DOI: 10.1002/hbm.24384
    Klooster, Deborah C.W. ; Franklin, Suzanne L. ; Besseling, René M.H. ; Jansen, Jaap F.A. ; Caeyenberghs, Karen ; Duprat, Romain ; Aldenkamp, Albert P. ; de Louw, Anton J.A. ; Boon, Paul A.J.M. ; Baeken, Chris. / Focal application of accelerated iTBS results in global changes in graph measures. In: Human Brain Mapping. 2019 ; Vol. 40, Nr. 2. blz. 432-450
    @article{82b099fce43348f480c3c73a43fdc370,
    title = "Focal application of accelerated iTBS results in global changes in graph measures",
    abstract = "Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.",
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    author = "Klooster, {Deborah C.W.} and Franklin, {Suzanne L.} and Besseling, {Ren{\'e} M.H.} and Jansen, {Jaap F.A.} and Karen Caeyenberghs and Romain Duprat and Aldenkamp, {Albert P.} and {de Louw}, {Anton J.A.} and Boon, {Paul A.J.M.} and Chris Baeken",
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    Focal application of accelerated iTBS results in global changes in graph measures. / Klooster, Deborah C.W. (Corresponding author); Franklin, Suzanne L.; Besseling, René M.H.; Jansen, Jaap F.A.; Caeyenberghs, Karen; Duprat, Romain; Aldenkamp, Albert P.; de Louw, Anton J.A.; Boon, Paul A.J.M.; Baeken, Chris.

    In: Human Brain Mapping, Vol. 40, Nr. 2, 01.02.2019, blz. 432-450.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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    AU - Klooster,Deborah C.W.

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    AU - Besseling,René M.H.

    AU - Jansen,Jaap F.A.

    AU - Caeyenberghs,Karen

    AU - Duprat,Romain

    AU - Aldenkamp,Albert P.

    AU - de Louw,Anton J.A.

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    AU - Baeken,Chris

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    AB - Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.

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    KW - transcranial magnetic stimulation

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    Klooster DCW, Franklin SL, Besseling RMH, Jansen JFA, Caeyenberghs K, Duprat R et al. Focal application of accelerated iTBS results in global changes in graph measures. Human Brain Mapping. 2019 feb 1;40(2):432-450. Beschikbaar vanaf, DOI: 10.1002/hbm.24384