Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

Marleen Kristen (Corresponding author), Madison J. Ainsworth (Corresponding author), Nino Chirico, Casper F.T. van der Ven, Pieter A. Doevendans, Joost P.G. Sluijter, Jos Malda, Alain van Mil (Corresponding author), Miguel Castilho (Corresponding author)

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Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

Originele taal-2Engels
Artikelnummer1900775
Pagina's (van-tot)e1900775
Aantal pagina's21
TijdschriftAdvanced Healthcare Materials
Volume9
Nummer van het tijdschrift1
Vroegere onlinedatum11 okt 2019
DOI's
StatusGepubliceerd - jan 2020

Vingerafdruk

Scaffolds
Organizations
Technology
Fibers
Tissue Engineering
Tissue engineering
Heart Failure
Repair
Tissue
Heart Transplantation
Cardiomyopathies
Blood pressure
Coronary Artery Disease
Cause of Death
Coronary Vessels
Myocardium
Myocardial Infarction
Hypertension
Growth
Fabrication

Citeer dit

Kristen, M., Ainsworth, M. J., Chirico, N., van der Ven, C. F. T., Doevendans, P. A., Sluijter, J. P. G., ... Castilho, M. (2020). Fiber scaffold patterning for mending hearts: 3D organization bringing the next step. Advanced Healthcare Materials, 9(1), e1900775. [1900775]. https://doi.org/10.1002/adhm.201900775
Kristen, Marleen ; Ainsworth, Madison J. ; Chirico, Nino ; van der Ven, Casper F.T. ; Doevendans, Pieter A. ; Sluijter, Joost P.G. ; Malda, Jos ; van Mil, Alain ; Castilho, Miguel. / Fiber scaffold patterning for mending hearts : 3D organization bringing the next step. In: Advanced Healthcare Materials. 2020 ; Vol. 9, Nr. 1. blz. e1900775.
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abstract = "Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.",
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Kristen, M, Ainsworth, MJ, Chirico, N, van der Ven, CFT, Doevendans, PA, Sluijter, JPG, Malda, J, van Mil, A & Castilho, M 2020, 'Fiber scaffold patterning for mending hearts: 3D organization bringing the next step', Advanced Healthcare Materials, vol. 9, nr. 1, 1900775, blz. e1900775. https://doi.org/10.1002/adhm.201900775

Fiber scaffold patterning for mending hearts : 3D organization bringing the next step. / Kristen, Marleen (Corresponding author); Ainsworth, Madison J. (Corresponding author); Chirico, Nino; van der Ven, Casper F.T.; Doevendans, Pieter A.; Sluijter, Joost P.G.; Malda, Jos; van Mil, Alain (Corresponding author); Castilho, Miguel (Corresponding author).

In: Advanced Healthcare Materials, Vol. 9, Nr. 1, 1900775, 01.2020, blz. e1900775.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

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Kristen M, Ainsworth MJ, Chirico N, van der Ven CFT, Doevendans PA, Sluijter JPG et al. Fiber scaffold patterning for mending hearts: 3D organization bringing the next step. Advanced Healthcare Materials. 2020 jan;9(1):e1900775. 1900775. https://doi.org/10.1002/adhm.201900775