Fetal autonomic response to severe acidaemia during labour

J.O.E.H. Laar, van, C.H.L. Peters, R. Vullings, S. Houterman, J.W.M. Bergmans, S.G. Oei

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 34 Citaties

Uittreksel

Objective Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. Design Case-control study. Setting Obstetric unit of a tertiary-care teaching hospital. Population Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH <7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. Methods Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. Main outcome measures Absolute power and normalised power in the low-frequency and high-frequency bands. Results No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). Conclusion The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition.
TaalEngels
Pagina's429-437
Aantal pagina's9
TijdschriftBJOG : An International Journal of Obstetrics and Gynaecology
Volume117
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 2009

Vingerafdruk

Fetus
Heart Rate
Autonomic Nervous System
Fetal Distress
Umbilical Arteries
Fourier Analysis
Tertiary Healthcare
Contraception
Teaching Hospitals
Obstetrics
Case-Control Studies
Electrocardiography
Outcome Assessment (Health Care)
Parturition
Population

Citeer dit

@article{0bd6aade61f64999ac688dea64eb06d4,
title = "Fetal autonomic response to severe acidaemia during labour",
abstract = "Objective Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. Design Case-control study. Setting Obstetric unit of a tertiary-care teaching hospital. Population Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH <7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. Methods Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. Main outcome measures Absolute power and normalised power in the low-frequency and high-frequency bands. Results No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). Conclusion The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition.",
author = "{Laar, van}, J.O.E.H. and C.H.L. Peters and R. Vullings and S. Houterman and J.W.M. Bergmans and S.G. Oei",
year = "2009",
doi = "10.1111/j.1471-0528.2009.02456.x",
language = "English",
volume = "117",
pages = "429--437",
journal = "BJOG : An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "4",

}

Fetal autonomic response to severe acidaemia during labour. / Laar, van, J.O.E.H.; Peters, C.H.L.; Vullings, R.; Houterman, S.; Bergmans, J.W.M.; Oei, S.G.

In: BJOG : An International Journal of Obstetrics and Gynaecology, Vol. 117, Nr. 4, 2009, blz. 429-437.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

TY - JOUR

T1 - Fetal autonomic response to severe acidaemia during labour

AU - Laar, van,J.O.E.H.

AU - Peters,C.H.L.

AU - Vullings,R.

AU - Houterman,S.

AU - Bergmans,J.W.M.

AU - Oei,S.G.

PY - 2009

Y1 - 2009

N2 - Objective Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. Design Case-control study. Setting Obstetric unit of a tertiary-care teaching hospital. Population Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH <7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. Methods Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. Main outcome measures Absolute power and normalised power in the low-frequency and high-frequency bands. Results No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). Conclusion The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition.

AB - Objective Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. Design Case-control study. Setting Obstetric unit of a tertiary-care teaching hospital. Population Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH <7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. Methods Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. Main outcome measures Absolute power and normalised power in the low-frequency and high-frequency bands. Results No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). Conclusion The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition.

U2 - 10.1111/j.1471-0528.2009.02456.x

DO - 10.1111/j.1471-0528.2009.02456.x

M3 - Article

VL - 117

SP - 429

EP - 437

JO - BJOG : An International Journal of Obstetrics and Gynaecology

T2 - BJOG : An International Journal of Obstetrics and Gynaecology

JF - BJOG : An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 4

ER -