TY - BOOK
T1 - Feedback and reversibility in substrate-enzyme reactions as discrete event models
AU - Zwieten, van, D.A.J.
AU - Rooda, J.E.
AU - Armbruster, H.D.
AU - Nagy, J.D.
PY - 2010
Y1 - 2010
N2 - A dierent approach in modeling reactions between substrate molecules and enzymes is
presented in this report. The reactions are modeled using a discrete event model (DEM),
mostly used in manufacturing or queueing systems. The DEM has been validated with the
most used approach to modeling substrate-enzyme reactions, a set of ordinary dierential
equations (ODEs). The substrate-enzyme model is extended with feedback of substrate
and=or product molecules on the enzyme, resulting in inhibition or activation of the
enzyme. A reversible reaction, where the enzyme can react with both the substrate
and the product, is also modeled as a DEM and validated with an ODE model. The
substrate-enzyme reaction models with feedback is extended to a steady-state system by
adding a generator, convertor and exit. Stability of the steady-state system is analyzed
and resulted in three distinct regions.
AB - A dierent approach in modeling reactions between substrate molecules and enzymes is
presented in this report. The reactions are modeled using a discrete event model (DEM),
mostly used in manufacturing or queueing systems. The DEM has been validated with the
most used approach to modeling substrate-enzyme reactions, a set of ordinary dierential
equations (ODEs). The substrate-enzyme model is extended with feedback of substrate
and=or product molecules on the enzyme, resulting in inhibition or activation of the
enzyme. A reversible reaction, where the enzyme can react with both the substrate
and the product, is also modeled as a DEM and validated with an ODE model. The
substrate-enzyme reaction models with feedback is extended to a steady-state system by
adding a generator, convertor and exit. Stability of the steady-state system is analyzed
and resulted in three distinct regions.
M3 - Report
T3 - SE report
BT - Feedback and reversibility in substrate-enzyme reactions as discrete event models
PB - Technische Universiteit Eindhoven
CY - Eindhoven
ER -