Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

Pieter Nieuwland; Ruth Segers; K. Koch; J.C.M. Hest, van; F.P.J.T. Rutjes

doi:10.1021/op100338z

Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

Pieter Nieuwland, Ruth Segers, K. Koch, J.C.M. Hest, van, F.P.J.T. Rutjes

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

52 Citaten (Scopus)

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A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 μL microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.

Originele taal-2	Engels
Pagina's (van-tot)	783-787
Aantal pagina's	5
Tijdschrift	Organic Process Research & Development
Volume	15
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1021/op100338z
Status	Gepubliceerd - 15 jul. 2011
Extern gepubliceerd	Ja

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Fast scale-up using microreactors: Pyrrole synthesis from micro to production scale

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