Fast scale up using microreactors: From microscale to production

P.J. Nieuwland, K. Koch, R. Becker, J.C.M. Hest, van, F.P.J.T. Rutjes

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.

Originele taal-2Engels
Titel14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pagina's995-997
Aantal pagina's3
Volume2
StatusGepubliceerd - 2010
Extern gepubliceerdJa
Evenement14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010) - Groningen, Nederland
Duur: 3 okt 20107 okt 2010
Congresnummer: 14
http://www.microtasconferences.org/microtas2010/

Congres

Congres14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010)
Verkorte titelMicroTAS 2010
LandNederland
StadGroningen
Periode3/10/107/10/10
Ander14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, the Netherlands
Internet adres

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  • Citeer dit

    Nieuwland, P. J., Koch, K., Becker, R., Hest, van, J. C. M., & Rutjes, F. P. J. T. (2010). Fast scale up using microreactors: From microscale to production. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 2, blz. 995-997)