Externally triggered glass transition switch for localized on-demand drug delivery

J.T.F. Keurentjes; M.F. Kemmere; H. Bruinewoud; M.A.M.E. Vertommen; S.A. Rovers; R. Hoogenboom; L.F.S. Stemkens; F.L.A.M.A. Peters; N.J.C. Tielen; D.T.A. Asseldonk, van; A.F. Gabriel; E.A. Joosten; M.A.E. Marcus

doi:10.1002/anie.200904172

Externally triggered glass transition switch for localized on-demand drug delivery

J.T.F. Keurentjes
, M.F. Kemmere
, H. Bruinewoud
, M.A.M.E. Vertommen
, S.A. Rovers
, R. Hoogenboom
, L.F.S. Stemkens
, F.L.A.M.A. Peters
, N.J.C. Tielen
, D.T.A. Asseldonk, van
, A.F. Gabriel
, E.A. Joosten
, M.A.E. Marcus

Chemical Engineering and Chemistry

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

40 Citaten (Scopus)

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want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).

Originele taal-2	Engels
Pagina's (van-tot)	9867-9870
Tijdschrift	Angewandte Chemie - International Edition
Volume	48
Nummer van het tijdschrift	52
DOI's	https://doi.org/10.1002/anie.200904172
Status	Gepubliceerd - 2009

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Keurentjes, J. T. F., Kemmere, M. F., Bruinewoud, H., Vertommen, M. A. M. E., Rovers, S. A., Hoogenboom, R., Stemkens, L. F. S., Peters, F. L. A. M. A., Tielen, N. J. C., Asseldonk, van, D. T. A., Gabriel, A. F., Joosten, E. A., & Marcus, M. A. E. (2009). Externally triggered glass transition switch for localized on-demand drug delivery. Angewandte Chemie - International Edition, 48(52), 9867-9870. https://doi.org/10.1002/anie.200904172

@article{ec74dad71c344a2eb1a49d5e9490ffcf,

title = "Externally triggered glass transition switch for localized on-demand drug delivery",

abstract = "want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).",

author = "J.T.F. Keurentjes and M.F. Kemmere and H. Bruinewoud and M.A.M.E. Vertommen and S.A. Rovers and R. Hoogenboom and L.F.S. Stemkens and F.L.A.M.A. Peters and N.J.C. Tielen and \{Asseldonk, van\}, D.T.A. and A.F. Gabriel and E.A. Joosten and M.A.E. Marcus",

year = "2009",

doi = "10.1002/anie.200904172",

language = "English",

volume = "48",

pages = "9867--9870",

journal = "Angewandte Chemie - International Edition",

issn = "0570-0833",

publisher = "Wiley",

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}

Keurentjes, JTF, Kemmere, MF, Bruinewoud, H, Vertommen, MAME, Rovers, SA, Hoogenboom, R, Stemkens, LFS, Peters, FLAMA, Tielen, NJC, Asseldonk, van, DTA, Gabriel, AF, Joosten, EA & Marcus, MAE 2009, 'Externally triggered glass transition switch for localized on-demand drug delivery', Angewandte Chemie - International Edition, vol. 48, nr. 52, blz. 9867-9870. https://doi.org/10.1002/anie.200904172

TY - JOUR

T1 - Externally triggered glass transition switch for localized on-demand drug delivery

AU - Keurentjes, J.T.F.

AU - Kemmere, M.F.

AU - Bruinewoud, H.

AU - Vertommen, M.A.M.E.

AU - Rovers, S.A.

AU - Hoogenboom, R.

AU - Stemkens, L.F.S.

AU - Peters, F.L.A.M.A.

AU - Tielen, N.J.C.

AU - Asseldonk, van, D.T.A.

AU - Gabriel, A.F.

AU - Joosten, E.A.

AU - Marcus, M.A.E.

PY - 2009

Y1 - 2009

N2 - want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).

AB - want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).

U2 - 10.1002/anie.200904172

DO - 10.1002/anie.200904172

M3 - Article

C2 - 19943293

SN - 0570-0833

VL - 48

SP - 9867

EP - 9870

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 52

ER -

Externally triggered glass transition switch for localized on-demand drug delivery

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