Ex vivo photoacoustic imaging of atherosclerotic carotid plaques

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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Uittreksel

Vulnerability assessment of carotid plaques is vital to prevent atherosclerosis-related mortality and disability. Photoacoustic imaging (PAI) in combination with plane-wave ultrasound (PUS) may have the ability to reveal the composition and the anatomical structure of the plaque, which infers its mechanical properties and vulnerability. In this study, we used PAI and PUS imaging to scan endarterectomy samples ex vivo, targeting intraplaque hemorrhage, and compared the results with those obtained in healthy (porcine) carotids and histology. A fully integrated hand-held photoacoustic probe was used, consisting of a pulsed diode laser (tp = 130 ns, Ep = 1 mJ, λ = 808 nm) and a linear array transducer (fc = 7.5 MHz). Three porcine carotid arteries and six carotid plaque samples were obtained from a local slaughterhouse and hospital respectively, and were mounted to the imaging setup. Data of endarterectomy samples revealed that PAI of carotid plaques at 808 nm wavelength is capable of detecting blood clots, which can be extensions of vasculature in the plaque, intra-plaque hemorrhage, or the result of trauma inflicted on the medial vascularization. Due to calcification and the limited optical penetration, imaging depth was mostly limited to the proximal wall of the samples. The porcine carotids revealed no hemorrhaging, which was corroborated by the lack of PAI contrast.

Originele taal-2Engels
Titel2015 IEEE International Ultrasonics Symposium, IUS 2015
UitgeverijInstitute of Electrical and Electronics Engineers
Aantal pagina's4
ISBN van geprinte versie9781479981823
DOI's
StatusGepubliceerd - 13 nov 2015
Evenement2015 IEEE International Ultrasonics Symposium (IUS 2015) - Taipei International Convention Center, Taipei, Taiwan
Duur: 21 okt 201524 okt 2015
http://ewh.ieee.org/conf/ius/ius_2015/

Congres

Congres2015 IEEE International Ultrasonics Symposium (IUS 2015)
Verkorte titel2015 IUS
LandTaiwan
StadTaipei
Periode21/10/1524/10/15
Internet adres

Vingerafdruk

hemorrhages
vulnerability
plane waves
disabilities
arteriosclerosis
calcification
histology
mortality
linear arrays
arteries
blood
transducers
penetration
semiconductor lasers
mechanical properties
probes
wavelengths

Citeer dit

Arabul, M. U., Heres, H. M., Rutten, M. C. M., van Sambeek, M. R. H. M., Van De Vosse, F. N., & Lopata, R. G. P. (2015). Ex vivo photoacoustic imaging of atherosclerotic carotid plaques. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329285] Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/ULTSYM.2015.0103
Arabul, M.U. ; Heres, H.M. ; Rutten, M.C.M. ; van Sambeek, M.R.H.M. ; Van De Vosse, F.N. ; Lopata, R.G.P. / Ex vivo photoacoustic imaging of atherosclerotic carotid plaques. 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers, 2015.
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title = "Ex vivo photoacoustic imaging of atherosclerotic carotid plaques",
abstract = "Vulnerability assessment of carotid plaques is vital to prevent atherosclerosis-related mortality and disability. Photoacoustic imaging (PAI) in combination with plane-wave ultrasound (PUS) may have the ability to reveal the composition and the anatomical structure of the plaque, which infers its mechanical properties and vulnerability. In this study, we used PAI and PUS imaging to scan endarterectomy samples ex vivo, targeting intraplaque hemorrhage, and compared the results with those obtained in healthy (porcine) carotids and histology. A fully integrated hand-held photoacoustic probe was used, consisting of a pulsed diode laser (tp = 130 ns, Ep = 1 mJ, λ = 808 nm) and a linear array transducer (fc = 7.5 MHz). Three porcine carotid arteries and six carotid plaque samples were obtained from a local slaughterhouse and hospital respectively, and were mounted to the imaging setup. Data of endarterectomy samples revealed that PAI of carotid plaques at 808 nm wavelength is capable of detecting blood clots, which can be extensions of vasculature in the plaque, intra-plaque hemorrhage, or the result of trauma inflicted on the medial vascularization. Due to calcification and the limited optical penetration, imaging depth was mostly limited to the proximal wall of the samples. The porcine carotids revealed no hemorrhaging, which was corroborated by the lack of PAI contrast.",
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Arabul, MU, Heres, HM, Rutten, MCM, van Sambeek, MRHM, Van De Vosse, FN & Lopata, RGP 2015, Ex vivo photoacoustic imaging of atherosclerotic carotid plaques. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329285, Institute of Electrical and Electronics Engineers, 2015 IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan, 21/10/15. https://doi.org/10.1109/ULTSYM.2015.0103

Ex vivo photoacoustic imaging of atherosclerotic carotid plaques. / Arabul, M.U.; Heres, H.M.; Rutten, M.C.M.; van Sambeek, M.R.H.M.; Van De Vosse, F.N.; Lopata, R.G.P.

2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers, 2015. 7329285.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - Heres, H.M.

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AU - Lopata, R.G.P.

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AB - Vulnerability assessment of carotid plaques is vital to prevent atherosclerosis-related mortality and disability. Photoacoustic imaging (PAI) in combination with plane-wave ultrasound (PUS) may have the ability to reveal the composition and the anatomical structure of the plaque, which infers its mechanical properties and vulnerability. In this study, we used PAI and PUS imaging to scan endarterectomy samples ex vivo, targeting intraplaque hemorrhage, and compared the results with those obtained in healthy (porcine) carotids and histology. A fully integrated hand-held photoacoustic probe was used, consisting of a pulsed diode laser (tp = 130 ns, Ep = 1 mJ, λ = 808 nm) and a linear array transducer (fc = 7.5 MHz). Three porcine carotid arteries and six carotid plaque samples were obtained from a local slaughterhouse and hospital respectively, and were mounted to the imaging setup. Data of endarterectomy samples revealed that PAI of carotid plaques at 808 nm wavelength is capable of detecting blood clots, which can be extensions of vasculature in the plaque, intra-plaque hemorrhage, or the result of trauma inflicted on the medial vascularization. Due to calcification and the limited optical penetration, imaging depth was mostly limited to the proximal wall of the samples. The porcine carotids revealed no hemorrhaging, which was corroborated by the lack of PAI contrast.

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SN - 9781479981823

BT - 2015 IEEE International Ultrasonics Symposium, IUS 2015

PB - Institute of Electrical and Electronics Engineers

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Arabul MU, Heres HM, Rutten MCM, van Sambeek MRHM, Van De Vosse FN, Lopata RGP. Ex vivo photoacoustic imaging of atherosclerotic carotid plaques. In 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers. 2015. 7329285 https://doi.org/10.1109/ULTSYM.2015.0103