ESHO benchmarks for computational modeling and optimization in hyperthermia therapy

Margarethus M. Paulides (Corresponding author), Dario B. Rodrigues, Gennaro G. Bellizzi, Kemal Sumser, Sergio Curto, Esra Neufeld, Hazael Montanaro, H. Petra Kok, Hana Dobsicek Trefna

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

24 Citaten (Scopus)
166 Downloads (Pure)

Samenvatting

BACKGROUND: The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment planning, optimization and decision making, as well as real-time treatment guidance.

MATERIALS AND METHODS: The same computational methods deployed in HTP are also used for in silico studies. These are of great relevance for the development of new HT devices and treatment approaches. To aid this work, 3 D patient models have been recently developed and made available for the HT community. Unfortunately, there is no consensus regarding tissue properties, simulation settings, and benchmark applicators, which significantly influence the clinical relevance of computational outcomes.

RESULTS AND DISCUSSION: Herein, we propose a comprehensive set of applicator benchmarks, efficacy and safety optimization algorithms, simulation settings and clinical parameters, to establish benchmarks for method comparison and code verification, to provide guidance, and in view of the 2021 ESHO Grand Challenge (Details on the ESHO grand challenge on HTP will be provided at https://www.esho.info/).

CONCLUSION: We aim to establish guidelines to promote standardization within the hyperthermia community such that novel approaches can quickly prove their benefit as quickly as possible in clinically relevant simulation scenarios. This paper is primarily focused on radiofrequency and microwave hyperthermia but, since 3 D simulation studies on heating with ultrasound are now a reality, guidance as well as a benchmark for ultrasound-based hyperthermia are also included.

Originele taal-2Engels
Pagina's (van-tot)1425-1442
Aantal pagina's18
TijdschriftInternational Journal of Hyperthermia
Volume38
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 28 sep. 2021

Financiering

This work was supported by COST Action MyWave CA17115 “European network for advancing Electromagnetic hyperthermic medical technologies”, Dutch Cancer Society proejct 11368 and the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845645.

FinanciersFinanciernummer
European Union’s Horizon Europe research and innovation programme
H2020 Marie Skłodowska-Curie Actions845645
European Cooperation in Science and Technology (COST)
KWF Kankerbestrijding11368

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