Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer; Sami Sanlidag; Carlijn V.C. Bouten; Cecilia M Sahlgren

doi:10.1016/j.tibtech.2022.01.007

Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten (Corresponding author), Cecilia M Sahlgren (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

9 Citaten (Scopus)

100 Downloads (Pure)

Samenvatting

Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

Originele taal-2	Engels
Pagina's (van-tot)	945-957
Aantal pagina's	13
Tijdschrift	Trends in Biotechnology
Volume	40
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1016/j.tibtech.2022.01.007
Status	Gepubliceerd - aug. 2022

Bibliografische nota

Financiering

This research was supported by the InFLAMES Flagship Programme of the Academy of Finland (decision 337530 ) (L.A.T., S.S., C.S.), the Academy of Finland ( 316882 , 330411 ) (S.S., C.S.), the European Research Council (ERC) under the EU Horizon 2020 Research and Innovation Programme (grant 771168 ) (C.S.) as well as the Åbo Akademi University Foundation Centers of Excellence in Cellular Mechanostasis and Bioelectronic Activation of Cell Functions (C.S.) and the Gravitation Program 'Materials Driven Regeneration' funded by the Netherlands Organization for Scientific Research ( 024.003.013 ) (C.B.). The figures in this article were created with BioRender.com .

Financiers	Financiernummer
European Union’s Horizon Europe research and innovation programme
European Research Council
Academy of Finland	337530, 330411, 316882
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.003.013
Horizon 2020	771168
Åbo Akademi University

Toegang tot document

10.1016/j.tibtech.2022.01.007

pdfDefinitieve gepubliceerde versie, 1,94 MBLicentie: CC BY

Andere bestanden en links

Link naar publicatie in Scopus

Citeer dit

@article{54c29a0f532544179dca18960fdd82b4,

title = "Engineering tissue morphogenesis: taking it up a Notch",

abstract = "Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.",

keywords = "ligand immobilization, morphogenesis, Notch signaling, Notch signaling modulation, tissue patterning",

author = "Tiemeijer, {Laura A.} and Sami Sanlidag and Bouten, {Carlijn V.C.} and Sahlgren, {Cecilia M}",

year = "2022",

month = aug,

doi = "10.1016/j.tibtech.2022.01.007",

language = "English",

volume = "40",

pages = "945--957",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - Engineering tissue morphogenesis

T2 - taking it up a Notch

AU - Tiemeijer, Laura A.

AU - Sanlidag, Sami

AU - Bouten, Carlijn V.C.

AU - Sahlgren, Cecilia M

PY - 2022/8

Y1 - 2022/8

N2 - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

AB - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

KW - ligand immobilization

KW - morphogenesis

KW - Notch signaling

KW - Notch signaling modulation

KW - tissue patterning

UR - http://www.scopus.com/inward/record.url?scp=85124668864&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2022.01.007

DO - 10.1016/j.tibtech.2022.01.007

M3 - Review article

C2 - 35181146

SN - 0167-7799

VL - 40

SP - 945

EP - 957

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 8

ER -

Engineering tissue morphogenesis: taking it up a Notch

Samenvatting

Bibliografische nota

Financiering

Toegang tot document

Andere bestanden en links

Vingerafdruk

Citeer dit