Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery

S. De Koker, J. Cui, N. Vanparijs, L. Albertazzi, J. Grooten, F. Caruso, B.G. De Geest

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

136 Citaten (Scopus)
368 Downloads (Pure)

Samenvatting

The induction of antigen-specific adaptive immunity exclusively occurs in lymphoid organs. As a consequence, the efficacy by which vaccines reach these tissues strongly affects the efficacy of the vaccine. Here, we report the design of polymer hydrogel nanoparticles that efficiently target multiple immune cell subsets in the draining lymph nodes. Nanoparticles are fabricated by infiltrating mesoporous silica particles (ca. 200 nm) with poly(methacrylic acid) followed by disulfide-based crosslinking and template removal. PEGylation of these nanoparticles does not affect their cellular association in vitro, but dramatically improves their lymphatic drainage in vivo. The functional relevance of these observations is further illustrated by the increased priming of antigen-specific T cells. Our findings highlight the potential of engineered hydrogel nanoparticles for the lymphatic delivery of antigens and immune-modulating compounds.

Originele taal-2Engels
Pagina's (van-tot)1334-1339
Aantal pagina's6
TijdschriftAngewandte Chemie - International Edition
Volume55
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 22 jan. 2016

Vingerafdruk

Duik in de onderzoeksthema's van 'Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery'. Samen vormen ze een unieke vingerafdruk.

Citeer dit