Engineering antimicrobial supramolecular polymer assemblies

Jiankang Song, Moniek G.J. Schmitz, Martijn Riool, Shuaiqi Guo, Sebastian A.J. Zaat, Patricia Y.W. Dankers (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

6 Citaten (Scopus)
36 Downloads (Pure)

Samenvatting

Antibacterial resistance against conventional antibiotics has emerged as a global health problem. To address this problem, antimicrobial peptides (AMPs) have been recognized as alternatives due to their fast-killing activity and less propensity to induce resistance. Here, the AMPs are engineered via a supramolecular fashion to control and increase their biological performance. The AMPs are modified with ureido-pyrimidinone (UPy) to obtain UPy-AMP monomers, followed by modular self-assembling to realize antibacterial UPy-AMP supramolecular polymers. These positively charged assemblies are illustrated as stable, short fibrous or rod-like UPy-AMP nanostructures with enhanced antibacterial activity and modulable cytotoxicity. Moreover, these antibacterial UPy-AMP assemblies can be internalized by both THP-1 derived macrophages and human kidney cells, which would be an effective potential therapy to deliver the AMPs into mammalian cells to address intracellular infections. Overall, the results present here demonstrate that supramolecular engineering of AMPs provides a powerful tool to enhance the antibacterial activity, modulate cytotoxicity and accelerate the clinical application of AMPs.

Originele taal-2Engels
Pagina's (van-tot)2866-2877
Aantal pagina's12
TijdschriftJournal of Polymer Science
Volume61
Nummer van het tijdschrift22
DOI's
StatusGepubliceerd - 15 nov. 2023

Bibliografische nota

Publisher Copyright:
© 2023 The Authors. Journal of Polymer Science published by Wiley Periodicals LLC.

Financiering

This work was supported by the Netherlands Cardiovascular Research Initiative (CVON 2012‐01), the European Research Council (FP7/2007–2013) ERC Grant Agreement 308045, the Dutch Polymer Institute (DPI) project 731.015.505, and the Dutch Ministry of Education, Culture and Science (Gravity programs 024.003.013 and 024.005.020).

FinanciersFinanciernummer
Netherlands Cardiovascular Research InitiativeCVON 2012‐01
Seventh Framework Programme
Dutch Polymer Institute (DPI)731.015.505
European Research Council308045
Ministerie van OCW024.005.020, 024.003.013

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