Emerging role of USPIOs for MR imaging of atherosclerosis

M.E. Kooi, S. Heeneman, M.J.A.P. Daemen, J.M.A. Engelshoven, van, K.B.J.M. Cleutjens

    Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademic

    Samenvatting

    Atherosclerosis is an inflammatory disease of the arteries, which causes more than 19 million deaths worldwide every year. Most complications of atherosclerosis are caused by rupture of a vulnerable plaque. Currently, there are no imaging techniques available in clinical practice that can accurately identify a vulnerable plaque. There is an emerging role for Ultrasmall Super-paramagnetic Iron Oxide Particles (USPIOs) in MR imaging of atherosclerosis. This review will first give an update on the biology of atherosclerosis. Next, we will focus on the physicochemical properties of USPIOs and describe animal and human studies that showed USPIO uptake mainly in macrophages of atherosclerotic plaque, which could be detected as areas of focal signal loss in MR images. Novel superparamagnetic particles are currently being developed which enable visualization of other cell types and functions than macrophage uptake that are relevant for atherosclerosis. We conclude that USPIOs are a highly promising imaging tool for atherosclerosis and larger prospective studies are warranted to prove the value in daily clinical practice.
    Originele taal-2Engels
    TitelNanoparticles in biomedical imaging: emerging technologies and applications
    RedacteurenM. Modo, J.W.M. Bulte
    Plaats van productieBerlin
    UitgeverijSpringer
    Pagina's63-90
    ISBN van geprinte versie978-0-387-72027-2
    DOI's
    StatusGepubliceerd - 2008

    Publicatie series

    NaamFundamental Biomedical Technologies
    Volume102
    ISSN van geprinte versie1559-7083

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