Embracing nanomaterials' interactions with the innate immune system

Abraham J.P. Teunissen (Corresponding author), Marianne E. Burnett, Geoffrey Prévot, Emma D. Klein, Daniel Bivona, Willem J.M. Mulder (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review


Immunotherapy has firmly established itself as a compelling avenue for treating disease. Although many clinically approved immunotherapeutics engage the adaptive immune system, therapeutically targeting the innate immune system remains much less explored. Nanomedicine offers a compelling opportunity for innate immune system engagement, as many nanomaterials inherently interact with myeloid cells (e.g., monocytes, macrophages, neutrophils, and dendritic cells) or can be functionalized to target their cell-surface receptors. Here, we provide a perspective on exploiting nanomaterials for innate immune system regulation. We focus on specific nanomaterial design parameters, including size, form, rigidity, charge, and surface decoration. Furthermore, we examine the potential of high-throughput screening and machine learning, while also providing recommendations for advancing the field. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Originele taal-2Engels
TijdschriftWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Nummer van het tijdschriftXX
Vroegere onlinedatum13 apr 2021
StatusE-publicatie vóór gedrukte publicatie - 13 apr 2021

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Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Copyright 2021 Elsevier B.V., All rights reserved.

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