Efficient computational simulation of actin stress fiber remodeling

T. Ristori, C. Obbink-Huizer, C.W.J. Oomens, F.P.T. Baaijens, S. Loerakker

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

9 Citaten (Scopus)
75 Downloads (Pure)

Samenvatting

Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.

Originele taal-2Engels
Pagina's (van-tot)1347-1358
Aantal pagina's12
TijdschriftComputer Methods in Biomechanics and Biomedical Engineering
Volume19
Nummer van het tijdschrift12
DOI's
StatusGepubliceerd - 28 jan 2016

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