Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion

S. Turco, C. Keravnou, R.J.G. van Sloun, H. Wijkstra, M. Averkiou, M. Mischi

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Uittreksel

Dynamic contrast enhanced ultrasound (DCE-US) enables imaging of cancer angiogenesis by quantification of perfusion and dispersion. Although increased perfusion may be found in areas of active angiogenesis due to increased demands for blood supply, decreased perfusion may be caused by the decreased efficiency and functionality, typical of cancer angiogenic microvasculature. Contrast dispersion, mainly determined by the flow profile in large vessels and by the multipath trajectories in the microvasculature, may thus represent a suitable alternative to characterize cancer angiogenesis. Based on a model of the contrast transport kinetics as a convective-dispersion process, several DCE-US methods have been proposed estimating dispersion for characterization of cancer angiogenic vasculature. Although dispersion imaging has shown promising in a clinical context, its physical link with variations in flow and vascular architecture has never been shown. The objective of this work is thus to investigate the influence of flow and underlying vascular architecture on the estimation of dispersion in an ex-vivo machine-perfused pig liver.
TaalEngels
Titel2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France
Plaats van productiePiscataway
UitgeverijInstitute of Electrical and Electronics Engineers (IEEE)
Aantal pagina's4
ISBN van geprinte versie978-1-4673-9897-8
DOI's
StatusGepubliceerd - 3 nov 2016
Evenement2016 IEEE International Ultrasonics Symposium (IUS 2016) - Convention Center Vinci, Tours, Frankrijk
Duur: 18 sep 201621 sep 2016
http://sites.ieee.org/ius-2016/

Publicatie series

NaamIEEE IUS
ISSN van elektronische versie1948-5727

Congres

Congres2016 IEEE International Ultrasonics Symposium (IUS 2016)
Verkorte titelIUS 2016
LandFrankrijk
StadTours
Periode18/09/1621/09/16
Internet adres

Vingerafdruk

Blood Vessels
Swine
Perfusion
Liver
Microvessels
Neoplasms
Ultrasonography

Citeer dit

Turco, S., Keravnou, C., van Sloun, R. J. G., Wijkstra, H., Averkiou, M., & Mischi, M. (2016). Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion. In 2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France (IEEE IUS). Piscataway: Institute of Electrical and Electronics Engineers (IEEE). DOI: 10.1109/ULTSYM.2016.7728488
Turco, S. ; Keravnou, C. ; van Sloun, R.J.G. ; Wijkstra, H. ; Averkiou, M. ; Mischi, M./ Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion. 2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France . Piscataway : Institute of Electrical and Electronics Engineers (IEEE), 2016. (IEEE IUS).
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title = "Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion",
abstract = "Dynamic contrast enhanced ultrasound (DCE-US) enables imaging of cancer angiogenesis by quantification of perfusion and dispersion. Although increased perfusion may be found in areas of active angiogenesis due to increased demands for blood supply, decreased perfusion may be caused by the decreased efficiency and functionality, typical of cancer angiogenic microvasculature. Contrast dispersion, mainly determined by the flow profile in large vessels and by the multipath trajectories in the microvasculature, may thus represent a suitable alternative to characterize cancer angiogenesis. Based on a model of the contrast transport kinetics as a convective-dispersion process, several DCE-US methods have been proposed estimating dispersion for characterization of cancer angiogenic vasculature. Although dispersion imaging has shown promising in a clinical context, its physical link with variations in flow and vascular architecture has never been shown. The objective of this work is thus to investigate the influence of flow and underlying vascular architecture on the estimation of dispersion in an ex-vivo machine-perfused pig liver.",
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Turco, S, Keravnou, C, van Sloun, RJG, Wijkstra, H, Averkiou, M & Mischi, M 2016, Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion. in 2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France . IEEE IUS, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, Tours, Frankrijk, 18/09/16. DOI: 10.1109/ULTSYM.2016.7728488

Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion. / Turco, S.; Keravnou, C.; van Sloun, R.J.G.; Wijkstra, H.; Averkiou, M.; Mischi, M.

2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France . Piscataway : Institute of Electrical and Electronics Engineers (IEEE), 2016. (IEEE IUS).

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - Turco,S.

AU - Keravnou,C.

AU - van Sloun,R.J.G.

AU - Wijkstra,H.

AU - Averkiou,M.

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N2 - Dynamic contrast enhanced ultrasound (DCE-US) enables imaging of cancer angiogenesis by quantification of perfusion and dispersion. Although increased perfusion may be found in areas of active angiogenesis due to increased demands for blood supply, decreased perfusion may be caused by the decreased efficiency and functionality, typical of cancer angiogenic microvasculature. Contrast dispersion, mainly determined by the flow profile in large vessels and by the multipath trajectories in the microvasculature, may thus represent a suitable alternative to characterize cancer angiogenesis. Based on a model of the contrast transport kinetics as a convective-dispersion process, several DCE-US methods have been proposed estimating dispersion for characterization of cancer angiogenic vasculature. Although dispersion imaging has shown promising in a clinical context, its physical link with variations in flow and vascular architecture has never been shown. The objective of this work is thus to investigate the influence of flow and underlying vascular architecture on the estimation of dispersion in an ex-vivo machine-perfused pig liver.

AB - Dynamic contrast enhanced ultrasound (DCE-US) enables imaging of cancer angiogenesis by quantification of perfusion and dispersion. Although increased perfusion may be found in areas of active angiogenesis due to increased demands for blood supply, decreased perfusion may be caused by the decreased efficiency and functionality, typical of cancer angiogenic microvasculature. Contrast dispersion, mainly determined by the flow profile in large vessels and by the multipath trajectories in the microvasculature, may thus represent a suitable alternative to characterize cancer angiogenesis. Based on a model of the contrast transport kinetics as a convective-dispersion process, several DCE-US methods have been proposed estimating dispersion for characterization of cancer angiogenic vasculature. Although dispersion imaging has shown promising in a clinical context, its physical link with variations in flow and vascular architecture has never been shown. The objective of this work is thus to investigate the influence of flow and underlying vascular architecture on the estimation of dispersion in an ex-vivo machine-perfused pig liver.

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Turco S, Keravnou C, van Sloun RJG, Wijkstra H, Averkiou M, Mischi M. Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion. In 2016 IEEE International Ultrasonics Symposium (IUS) , 18-21 Sept. 2016, Tours, France . Piscataway: Institute of Electrical and Electronics Engineers (IEEE). 2016. (IEEE IUS). Beschikbaar vanaf, DOI: 10.1109/ULTSYM.2016.7728488