Effect of small motor unit potentials on the motor unit number estimate

Johannes P van Dijk, Machiel J Zwarts, Helenius J Schelhaas, Dick F Stegeman

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

11 Citaten (Scopus)

Samenvatting

Small surface motor unit potentials (S-MUPs) may have a negative influence on the variability of the motor unit number estimate (MUNE). According to published consensus criteria S-MUPs with a negative peak amplitude smaller than 10 muV should be omitted. The effect of omitting small S-MUPs on the MUNE was evaluated using a simulation model. The model incorporated a healthy and amyotrophic lateral sclerosis (ALS) distribution formed with real S-MUPs. Using a random drawing process the MUNE was calculated with and without small S-MUPs. In the healthy population 27% of all S-MUPs were small. MUNE determined without these S-MUPs was marginally less variable. However, MUNE values dropped about 24% at a sample size of 20. In ALS, only 12% of the total population of 130 S-MUPs were small. MUNE dropped about 12% without the small S-MUPs. By omitting small S-MUPs the differences between the healthy and ALS distributions become smaller. Therefore, incorporating small S-MUPs in the estimate is suggested.

Originele taal-2Engels
Pagina's (van-tot)887-892
Aantal pagina's6
TijdschriftMuscle and nerve
Volume38
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - jul 2008
Extern gepubliceerdJa

Bibliografische nota

(c) 2008 Wiley Periodicals, Inc.

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