Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Uittreksel

Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.

TaalEngels
TitelMeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings
Plaats van productiePiscataway
UitgeverijInstitute of Electrical and Electronics Engineers
Aantal pagina's6
ISBN van elektronische versie978-1-5386-3392-2
ISBN van geprinte versie978-1-5386-3393-9
DOI's
StatusGepubliceerd - 16 aug 2018
Evenement13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 - Rome, Italië
Duur: 11 jun 201813 jun 2018

Congres

Congres13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018
LandItalië
StadRome
Periode11/06/1813/06/18

Vingerafdruk

Cardiac resynchronization therapy
Cardiac Resynchronization Therapy
Heart Ventricles
therapy
blood flow
Ultrasonics
Pressure
transponders
Blood
Speckle
Vorticity
Flow patterns
vorticity
flow distribution
Ventricular Dysfunction
Blood Flow Velocity
Aortic Valve
ejection
Flow velocity
Dilution

Trefwoorden

    Citeer dit

    Chen, P., van Sloun, R. J. G., Turco, S., Wijkstra, H., Houthuizen, P., & Mischi, M. (2018). Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. In MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings [8438752] Piscataway: Institute of Electrical and Electronics Engineers. DOI: 10.1109/MeMeA.2018.8438752
    Chen, Peiran ; van Sloun, Ruud J.G. ; Turco, Simona ; Wijkstra, Hessel ; Houthuizen, Patrick ; Mischi, Massimo. / Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway : Institute of Electrical and Electronics Engineers, 2018.
    @inproceedings{76ba112014b149009a1d60e48f91d71f,
    title = "Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates",
    abstract = "Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.",
    keywords = "contrast ultrasound, Left ventricle, velocity vector fields, ventricular pressure, vorticity",
    author = "Peiran Chen and {van Sloun}, {Ruud J.G.} and Simona Turco and Hessel Wijkstra and Patrick Houthuizen and Massimo Mischi",
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    Chen, P, van Sloun, RJG, Turco, S, Wijkstra, H, Houthuizen, P & Mischi, M 2018, Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. in MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings., 8438752, Institute of Electrical and Electronics Engineers, Piscataway, Rome, Italië, 11/06/18. DOI: 10.1109/MeMeA.2018.8438752

    Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. / Chen, Peiran; van Sloun, Ruud J.G.; Turco, Simona; Wijkstra, Hessel; Houthuizen, Patrick; Mischi, Massimo.

    MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway : Institute of Electrical and Electronics Engineers, 2018. 8438752.

    Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

    TY - GEN

    T1 - Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates

    AU - Chen,Peiran

    AU - van Sloun,Ruud J.G.

    AU - Turco,Simona

    AU - Wijkstra,Hessel

    AU - Houthuizen,Patrick

    AU - Mischi,Massimo

    PY - 2018/8/16

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    N2 - Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.

    AB - Clinical studies indicate that dysfunction of the left ventricle occurs at an early stage of heart-failure. As ventricular dysfunction and cardiac disease affect the intraventricular flow patterns, analysis of blood flow and relative pressure may aid diagnosis. Several visualization tools exist that are generally based on speckle-tracking techniques using ultrafast ultrasound acquisitions. Yet, there is a need for techniques that can deal with low frame rates, in particular when envisioning future translation to 3D imaging. Here, blood flow velocity and relative pressure are estimated with low-frame-rate dynamic contrast-enhanced ultrasound (DCE-US). Different from standard speckle-tracking techniques, here we propose a method based on estimation of time-delays between indicator dilution curves measured from a set of neighboring pixels in the DCE-US video. An improved estimation of the velocity vectors is then obtained by Navier-Stokes regularization. Using the regularized velocity vectors, relative pressures can be calculated. Blood flow patterns were characterized in terms of vorticity, quantified by the curl of the velocity vectors, and changes in relative pressure (dp/dt) around the aortic valve, since these are linked to the ejection efficiency. Eighteen patients, who underwent cardiac resynchronization therapy (CRT) (9 for CRT-responder and 9 for CRT-non-responder), were tested with the algorithm. In the responder group, vorticity and peak dp/dt were significantly increased after CRT, while no significant difference was found in the non-responder group.

    KW - contrast ultrasound

    KW - Left ventricle

    KW - velocity vector fields

    KW - ventricular pressure

    KW - vorticity

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    U2 - 10.1109/MeMeA.2018.8438752

    DO - 10.1109/MeMeA.2018.8438752

    M3 - Conference contribution

    SN - 978-1-5386-3393-9

    BT - MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings

    PB - Institute of Electrical and Electronics Engineers

    CY - Piscataway

    ER -

    Chen P, van Sloun RJG, Turco S, Wijkstra H, Houthuizen P, Mischi M. Dynamic velocity vector and relative pressure estimation in the left ventricle with dynamic contrast-enhanced ultrasound of low frame rates. In MeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings. Piscataway: Institute of Electrical and Electronics Engineers. 2018. 8438752. Beschikbaar vanaf, DOI: 10.1109/MeMeA.2018.8438752