Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado; Bas J H M Rosier; Tom F A de Greef; Luc Brunsveld

doi:10.1039/d0cc02120b

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado, Bas J H M Rosier, Tom F A de Greef, Luc Brunsveld (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

2 Citaten (Scopus)

Samenvatting

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

Originele taal-2	Engels
Pagina's (van-tot)	5747-5750
Aantal pagina's	4
Tijdschrift	Chemical Communications, ChemComm
Volume	56
Nummer van het tijdschrift	43
Vroegere onlinedatum	22 apr. 2020
DOI's	https://doi.org/10.1039/d0cc02120b
Status	Gepubliceerd - 28 mei 2020

Financiering

This work was supported by The Netherlands Organization for Scientific Research (NWO) through Gravity Program 024.001.035, and through the European Union’s program Horizon 2020 Marie Curie Innovative Training Network MULTI APP (2015-2019).

Financiers	Financiernummer
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Horizon 2020 Framework Programme	677313
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.001.035
Horizon 2020	2015-2019

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Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

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