Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Eva Magdalena Estirado, Bas J H M Rosier, Tom F A de Greef, Luc Brunsveld (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Samenvatting

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

Originele taal-2Engels
Pagina's (van-tot)5747-5750
Aantal pagina's4
TijdschriftChemical Communications
Volume56
Nummer van het tijdschrift43
Vroegere onlinedatum22 apr 2020
DOI's
StatusGepubliceerd - 28 mei 2020

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