Discrete event simulations for glycolysis pathway and energy balance

D.A.J. Zwieten, van, J.E. Rooda, H.D. Armbruster, J.D. Nagy

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    Samenvatting

    In this report, the biological network of the glycolysis pathway has been modeled using discrete event models (DEMs). The most important feature of this pathway is that energy is released. To create a stable steady-state system an energy molecule equilibrating enzyme and metabolic reactions have been added, resulting in the energy balance system. Stability and stochastic in uences on the results have been investigated and result in an unstable system, except for a small region of input parameters. To stabilize the energy balance system some feedback regulators are presented. It is shown that stochastic behavior has got a signicant in uence on a otherwise stable biological system.
    Originele taal-2Engels
    Plaats van productieEindhoven
    UitgeverijTechnische Universiteit Eindhoven
    Aantal pagina's79
    StatusGepubliceerd - 2010

    Publicatie series

    NaamSE report
    Volume2010-02
    ISSN van geprinte versie1872-1567

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