Uittreksel
Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the generation of well-defined nanotubes based on polymersomes as small as 250 and 100 nm, which can be successfully shape transformed. The quality of the resulting nanostructures was established by physical characterization using AF4-MALS and cryo-TEM. Moreover, we show the successful loading of such nanotubes with model payloads (proteins and drugs). These findings provide a promising platform for implementation in biomedical applications in which discrete structure and functionality are essential features.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 177-183 |
| Aantal pagina's | 7 |
| Tijdschrift | Biomacromolecules |
| Volume | 20 |
| Nummer van het tijdschrift | 1 |
| DOI's | |
| Status | Gepubliceerd - 14 jan 2019 |
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Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine. / Wauters, Annelies C.; Pijpers, Imke A.B.; Mason, Alexander F.; Williams, David S.; Tel, Jurjen; Abdelmohsen, Loai K.E.A. (Corresponding author); van Hest, Jan C.M. (Corresponding author).
In: Biomacromolecules, Vol. 20, Nr. 1, 14.01.2019, blz. 177-183.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
TY - JOUR
T1 - Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine
AU - Wauters, Annelies C.
AU - Pijpers, Imke A.B.
AU - Mason, Alexander F.
AU - Williams, David S.
AU - Tel, Jurjen
AU - Abdelmohsen, Loai K.E.A.
AU - van Hest, Jan C.M.
PY - 2019/1/14
Y1 - 2019/1/14
N2 - Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the generation of well-defined nanotubes based on polymersomes as small as 250 and 100 nm, which can be successfully shape transformed. The quality of the resulting nanostructures was established by physical characterization using AF4-MALS and cryo-TEM. Moreover, we show the successful loading of such nanotubes with model payloads (proteins and drugs). These findings provide a promising platform for implementation in biomedical applications in which discrete structure and functionality are essential features.
AB - Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the generation of well-defined nanotubes based on polymersomes as small as 250 and 100 nm, which can be successfully shape transformed. The quality of the resulting nanostructures was established by physical characterization using AF4-MALS and cryo-TEM. Moreover, we show the successful loading of such nanotubes with model payloads (proteins and drugs). These findings provide a promising platform for implementation in biomedical applications in which discrete structure and functionality are essential features.
UR - http://www.scopus.com/inward/record.url?scp=85055131465&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.8b01245
DO - 10.1021/acs.biomac.8b01245
M3 - Article
C2 - 30265794
VL - 20
SP - 177
EP - 183
JO - Biomacromolecules
JF - Biomacromolecules
SN - 1525-7797
IS - 1
ER -