Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection

E.A. Bruijn, de; U.R. Tjaden; A.T. Oosterom, van; P. Leeflang; P.A. Leclercq

Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection

E.A. Bruijn, de
, U.R. Tjaden
, A.T. Oosterom, van
, P. Leeflang
, P.A. Leclercq

Chemical Engineering and Chemistry

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Professioneel

Samenvatting

A rapid and sensitive method to determine cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one run has been developed. SCOT OV 275 columns were combined with Electron Capture Detection (ECD) and Nitrogen Phosphorus Selective Detection (NPSD). The influence of the column diameter on the separation is shown. The extraction with i-propanol/ether (22/77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The assay is applied to some pharmacokinetic experiments concerning chemotherapeutically treated patients and one WAG/Rij rat.

Originele taal-2	Engels
Titel	Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy
Redacteuren	J.A. Rijks
Plaats van productie	Amsterdam
Uitgeverij	Elsevier
Pagina's	693-701
Status	Gepubliceerd - 1983
Evenement	5th International Symposium on Capillary Chromatography, April 26-28, 1983, Riva del Garda, Italy - Riva del Garda, Italië Duur: 26 apr. 1983 → 28 apr. 1983

Congres

Congres	5th International Symposium on Capillary Chromatography, April 26-28, 1983, Riva del Garda, Italy
Land/Regio	Italië
Stad	Riva del Garda
Periode	26/04/83 → 28/04/83
Ander	International Symposium on Capillary Chromatography ; 5 (Riva del Garda) : 1983.04.26-28

Citeer dit

Bruijn, de, E. A., Tjaden, U. R., Oosterom, van, A. T., Leeflang, P., & Leclercq, P. A. (1983). Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection. In J. A. Rijks (editor), Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy (blz. 693-701). Elsevier.

Bruijn, de, E.A. ; Tjaden, U.R. ; Oosterom, van, A.T. et al. / Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection. Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy. redacteur / J.A. Rijks. Amsterdam : Elsevier, 1983. blz. 693-701

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title = "Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection",

abstract = "A rapid and sensitive method to determine cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one run has been developed. SCOT OV 275 columns were combined with Electron Capture Detection (ECD) and Nitrogen Phosphorus Selective Detection (NPSD). The influence of the column diameter on the separation is shown. The extraction with i-propanol/ether (22/77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The assay is applied to some pharmacokinetic experiments concerning chemotherapeutically treated patients and one WAG/Rij rat.",

author = "\{Bruijn, de\}, E.A. and U.R. Tjaden and \{Oosterom, van\}, A.T. and P. Leeflang and P.A. Leclercq",

year = "1983",

language = "English",

pages = "693--701",

editor = "J.A. Rijks",

booktitle = "Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy",

publisher = "Elsevier",

address = "Netherlands",

note = "5th International Symposium on Capillary Chromatography, April 26-28, 1983, Riva del Garda, Italy ; Conference date: 26-04-1983 Through 28-04-1983",

}

Bruijn, de, EA, Tjaden, UR, Oosterom, van, AT, Leeflang, P & Leclercq, PA 1983, Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection. in JA Rijks (uitgave), Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy. Elsevier, Amsterdam, blz. 693-701, 5th International Symposium on Capillary Chromatography, April 26-28, 1983, Riva del Garda, Italy, Riva del Garda, Italië, 26/04/83.

Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection. / Bruijn, de, E.A.; Tjaden, U.R.; Oosterom, van, A.T. et al.
Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy. uitgave / J.A. Rijks. Amsterdam: Elsevier, 1983. blz. 693-701.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Professioneel

TY - GEN

T1 - Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection

AU - Bruijn, de, E.A.

AU - Tjaden, U.R.

AU - Oosterom, van, A.T.

AU - Leeflang, P.

AU - Leclercq, P.A.

PY - 1983

Y1 - 1983

N2 - A rapid and sensitive method to determine cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one run has been developed. SCOT OV 275 columns were combined with Electron Capture Detection (ECD) and Nitrogen Phosphorus Selective Detection (NPSD). The influence of the column diameter on the separation is shown. The extraction with i-propanol/ether (22/77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The assay is applied to some pharmacokinetic experiments concerning chemotherapeutically treated patients and one WAG/Rij rat.

AB - A rapid and sensitive method to determine cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one run has been developed. SCOT OV 275 columns were combined with Electron Capture Detection (ECD) and Nitrogen Phosphorus Selective Detection (NPSD). The influence of the column diameter on the separation is shown. The extraction with i-propanol/ether (22/77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The assay is applied to some pharmacokinetic experiments concerning chemotherapeutically treated patients and one WAG/Rij rat.

M3 - Conference contribution

SP - 693

EP - 701

BT - Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy

A2 - Rijks, J.A.

PB - Elsevier

CY - Amsterdam

T2 - 5th International Symposium on Capillary Chromatography, April 26-28, 1983, Riva del Garda, Italy

Y2 - 26 April 1983 through 28 April 1983

ER -

Bruijn, de EA, Tjaden UR, Oosterom, van AT, Leeflang P, Leclercq PA. Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection. In Rijks JA, redacteur, Proceedings of the 5th International symposium on capillary gas chromatography, Riva del Garda, Italy. Amsterdam: Elsevier. 1983. blz. 693-701

Determination of the underivatized antineoplastic drugs CP, 5-FU and somE of their metabolites by capillary gas chromatography combined with electron capture and nitrogen-phosphorous selective detection

Samenvatting

Congres

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