Determination of physiological parameters of tissue from dynamic contrast-enhanced MR data

A method of determining microvascular architecture is disclosed. Dynamic contrast-enhanced magnetic resonance data acquired from a contrast agent administered to at least a part of a subject to be examined. From the dynamic contrast-enhanced magnetic resonance data a leakage parameter (k ep) and a dispersion parameter (k) are computed. Effects of both convective dispersion and extravasation kinetics of contrast agent are taken into account.