Samenvatting
Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 375–388 |
| Aantal pagina's | 14 |
| Tijdschrift | Nature Reviews. Immunology |
| Volume | 20 |
| Nummer van het tijdschrift | 6 |
| Vroegere onlinedatum | 4 mrt. 2020 |
| DOI's | |
| Status | Gepubliceerd - jun. 2020 |
Financiering
M.G.N. was supported by a Spinoza grant from the Netherlands Organization for Scientific Research and a European Research Council (ERC) Advanced Grant (no. 833247). E.F. is an Investigator of the Howard Hughes Medical Institute and is supported by grants from the US National Institutes of Health (R01-AR31737 and R01-AR050452) and New York State (C32585GG). J.C.S. is supported by the Ludwig Center for Cancer Immunotherapy, the American Cancer Society, the Burroughs Wellcome Fund and the US National Institutes of Health (AI100874, AI130043 and P30CA008748). E.L. is supported by grants from the Deutsche Forschungsgemeins-chaft (SFBs 645, 670 and 1123; TRRs 83 and 57), a grant from the US National Institutes of Health (1R01HL112661) and an ERC Consolidator grant (InflammAct). J.L.S is supported by grants from the Deutsche Forschungsgemeinschaft (West German Genome Center grant, Central Coordination Unit of the national Next-Generation Sequencing Competence Network) and grants from the Helmholtz Gemeinschaft (Sparse2Big and AmPro) and the European Union (SYSCID, no. 733100). E.L., M.G.N., J.L.S. and A.S. are members of the Immuno-Sensation excellence cluster funded by the Deutsche Forschungsgemeins-chaft under Germany’s Excellence Strategy (EXC2151 — 390873048). T.C. is supported by an ERC Consolidator grant (DEMETINL) and by grants from the Deutsche Forschungs-gemeinschaft (SFB 1181, TRR-SFB 205 and TRR-SFB 127). N.P.R., L.A.B.J. and M.G.N. received funding from the European Union Horizon 2020 research and innovation programme under grant agreement no. 667837 and the IN-CONTROL grant from the Dutch Foundation Netherlands (CVON2012-03 and CVON2018-27). N.P.R. is a recipient of a grant from European Research Area Network on Cardiovascular Diseases Joint Transnational Call 2018, which is supported by the Dutch Heart Foundation (JTC2018, project MEMORY; 2018T093).