Daily energy expenditure through the human life course

International Atomic Energy Agency Doubly Labeled Water database group; Carlijn V.C. Bouten

doi:10.1126/science.abe5017

Daily energy expenditure through the human life course

International Atomic Energy Agency Doubly Labeled Water database group, Carlijn V.C. Bouten

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

255 Citaten (Scopus)

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Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Originele taal-2	Engels
Artikelnummer	eabe5017
Pagina's (van-tot)	808-812
Aantal pagina's	5
Tijdschrift	Science
Volume	373
Nummer van het tijdschrift	6556
DOI's	https://doi.org/10.1126/science.abe5017
Status	Gepubliceerd - 13 aug. 2021

Bibliografische nota

Financiering

Financiers	Financiernummer
SERCON
Taiyo Nippon Sanso
National Science Foundation(NSF)	BCS-1824466
National Institute on Aging	R01AG029914, U01AG020478, U01AG022132, R56AG067200, U01AG020480
National Cancer Institute	R01CA119171
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK080763, R01DK085163, P30DK072476, R01DK074387, R01DK080760, R01DK056781, K23DK068052, R01DK030031
National Institute of Arthritis and Musculoskeletal and Skin Diseases	U01AR071160
National Institute of Child Health and Human Development	ZIAHD000641
National Center for Research Resources	S10RR026764
International Atomic Energy Agency

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10.1126/science.abe5017

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@article{bd8cdd7629d443b9bc8b645415899a8b,

title = "Daily energy expenditure through the human life course",

abstract = "Total daily energy expenditure ({"}total expenditure{"}) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",

author = "{International Atomic Energy Agency Doubly Labeled Water database group} and Herman Pontzer and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, {Philip N.} and Andersen, {Lene F.} and Anderson, {Liam J.} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn V.C.} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.} and Close, {Graeme L.} and Cooper, {Jamie A.} and Richard Cooper and Das, {Sai Krupa} and Dugas, {Lara R.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W.} and Goris, {Annelies H.} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marjije B.} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M.} and Peter Katzmarzyk and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Lambert, {Estelle V.} and Leonard, {William R.} and Nader Lessan and Corby Martin and Medin, {Anine C.} and Meijer, {Erwin P.} and Morehen, {James C.} and Morton, {James P.} and Neuhouser, {Marian L.} and Guy Plasqui and Westerterp, {Klaas R.}",

note = "Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2021",

month = aug,

day = "13",

doi = "10.1126/science.abe5017",

language = "English",

volume = "373",

pages = "808--812",

journal = "Science",

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publisher = "American Association for the Advancement of Science (AAAS)",

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AU - Pontzer, Herman

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Ainslie, Philip N.

AU - Andersen, Lene F.

AU - Anderson, Liam J.

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E.

AU - Blanc, Stephane

AU - Bonomi, Alberto G.

AU - Bouten, Carlijn V.C.

AU - Bovet, Pascal

AU - Buchowski, Maciej S.

AU - Butte, Nancy F.

AU - Camps, Stefan G.

AU - Close, Graeme L.

AU - Cooper, Jamie A.

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W.

AU - Goris, Annelies H.

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marjije B.

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M.

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P.

AU - Kimura, Misaka

AU - Kraus, William E.

AU - Kushner, Robert F.

AU - Lambert, Estelle V.

AU - Leonard, William R.

AU - Lessan, Nader

AU - Martin, Corby

AU - Medin, Anine C.

AU - Meijer, Erwin P.

AU - Morehen, James C.

AU - Morton, James P.

AU - Neuhouser, Marian L.

AU - Plasqui, Guy

AU - Westerterp, Klaas R.

PY - 2021/8/13

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N2 - Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

AB - Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

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U2 - 10.1126/science.abe5017

DO - 10.1126/science.abe5017

M3 - Article

C2 - 34385400

SN - 0036-8075

VL - 373

SP - 808

EP - 812

JO - Science

JF - Science

IS - 6556

M1 - eabe5017

ER -

Daily energy expenditure through the human life course

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Duurzame ontwikkelingsdoelstellingen van de VN

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