Cumulative Phase Delay Imaging - a new contrast enhanced ultrasound modality

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Recently, a new acoustic marker for ultrasound contrast agents (UCAs) has been introduced. A cumulative phase delay (CPD) between the second harmonic and fundamental pressure wave field components is in fact observable for ultrasound propagating through UCAs. This phenomenon is absent in the case of tissue nonlinearity and is dependent on insonating pressure and frequency, UCA concentration, and propagation path length through UCAs. In this paper, ultrasound images based on this marker are presented. The ULA-OP research platform, in combination with a LA332 linear array probe (Esaote, Firenze Italy), were used to image a gelatin phantom containing a PVC plate (used as a reflector) and a cylindrical cavity measuring 7 mm in diameter (placed in between the observation point and the PVC plate). The cavity contained a 240 µL/L SonoVueO® UCA concentration. Two insonating frequencies (3 MHz and 2.5 MHz) were used to scan the gelatine phantom. A mechanical index MI = 0.07, measured in water at the cavity location with a HGL-0400 hydrophone (Onda, Sunnyvale, CA), was utilized. Processing the ultrasound signals backscattered from the plate, ultrasound images were generated in a tomographic fashion using the filtered back-projection method. As already observed in previous studies, significantly higher CPD values are measured when imaging at a frequency of 2.5 MHz, as compared to imaging at 3 MHz. In conclusion, these results confirm the applicability of the discussed CPD as a marker for contrast imaging. Comparison with standard contrast-enhanced ultrasound imaging modalities will be the focus of future work.
Originele taal-2Engels
TitelRecent Developments in Nonlinear Acoustics
Subtitel20th International Symposium on Nonlinear Acoustics including the 2nd International Sonic Boom Forum
UitgeverijAmerican Institute of Physics
Aantal pagina's5
ISBN van geprinte versie 978-0-7354-1332-0
DOI's
StatusGepubliceerd - 2015

Publicatie series

NaamAIP Conference Proceedings
UitgeverijAmerican Institute of Physics
Volume1685
ISSN van geprinte versie0094-243X

Citeer dit

Demi, L., van Sloun, R. J. G., Wijkstra, H., & Mischi, M. (2015). Cumulative Phase Delay Imaging - a new contrast enhanced ultrasound modality. In Recent Developments in Nonlinear Acoustics: 20th International Symposium on Nonlinear Acoustics including the 2nd International Sonic Boom Forum (AIP Conference Proceedings; Vol. 1685). American Institute of Physics. https://doi.org/10.1063/1.4934407