COVID-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy

J.E. Mongula, M.W.E. Frenken (Corresponding author), G. van Lijnschoten, N.L.A. Arents, L.D. de Wit-Zuurendonk, A.P.A. Schimmel-de Kok, P.J. van Runnard Heimel, M.M. Porath, S.M.T.A. Goossens

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

50 Citaten (Scopus)


We report a case of a pregnant woman with COVID-19 who developed coagulopathy in the absence of severe clinical symptoms. A polymerase chain reaction test of a vaginal swab was positive for SARS-CoV-2 RNA, suggesting a possibility of perinatal transmission. Cesarean delivery was performed because of a non-reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. Moreover, placental infection with SARS-CoV-2 was demonstrated by placental immunostaining. The findings suggest a possible relationship between placental fibrin deposition and chronic and acute intervillositis, non-reassuring fetal heart rate and coagulopathy in pregnant women with COVID-19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Originele taal-2Engels
Pagina's (van-tot)773-776
Aantal pagina's4
TijdschriftUltrasound in Obstetrics and Gynecology
Nummer van het tijdschrift5
Vroegere onlinedatum27 aug. 2020
StatusGepubliceerd - 1 nov. 2020


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