Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study

Chris Baeken, Vince van Beek, Marie Anne Vanderhasselt, Romain Duprat, Debby Klooster (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Samenvatting

Objectives: Accelerated intermittent theta burst stimulation (aiTBS) is a promising treatment option for depressed patients. However, there is a large interindividual variability in clinical effectiveness and individual biomarkers to guide treatment outcome are needed. Materials and Methods: Here, the relation between cortical thickness and clinical response (17-item Hamilton Depression Rating Scale) was studied using anatomical MRI data of 50 depressed patients who were included in a randomized, sham-controlled, double-blinded, cross-over aiTBS design (NCT01832805). Results: Baseline cortical thickness in the right caudal part of the anterior cingulate cortex (cACC) was significantly correlated with direct clinical responses in the subgroup who received active aiTBS during the first stimulation week. No correlations were found between baseline cortical thickness and delayed clinical effectiveness. In this particular region, longitudinal changes in cortical thickness were significantly correlated with clinical effectiveness. Furthermore, direct changes in cortical thickness in the right cACC showed predictive potential of delayed clinical responses. Conclusion: Cortical thickness within the right cACC might be an important biomarker to predict clinical responses to aiTBS. Additional studies are warranted to substantiate the specific biomarker potential of these parts of the ACC.

Originele taal-2Engels
TijdschriftNeuromodulation
VolumeXX
Nummer van het tijdschriftXX
DOI's
StatusE-publicatie vóór gedrukte publicatie - 31 mrt 2021

Bibliografische nota

Funding Information:
Source(s) of financial support: Chris Baeken and Debby Klooster were supported by the “Rode Neuzen” funding for scientific research [grant number G0F4617N], the Ghent University Multidisciplinary Research Partnership “The integrative neuroscience of behavioral control”, and a grant BOF16/GOA/017 for a Concerted Research Action of Ghent University, Marie‐Anne Vanderhasselt is supported by grant BOFSTA2017002501 for research at Ghent University.

Publisher Copyright:
© 2021 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals LLC on behalf of International Neuromodulation Society.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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