Contrast-enhanced T1-mapping MRI for the assessment of myocardial fibrosis

W.L. de Graaf, K. Vandoorne, F. Arslan, K. Nicolaij, G.J. Strijkers

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Uittreksel

Fibrosis is a common feature of heart disease and is associated with adverse cardiac remodeling and poor clinical outcome. Because of the lack of routine noninvasive patient-specific tissue characterization tools, the development of new treatment strategies for cardiovascular disease specifically targeting undesired fibrosis in the myocardial wall is slow. Cardiovascular magnetic resonance imaging has developed into the gold-standard tool to assess various aspects of myocardial anatomy and function. In recent years, magnetic resonance imaging has also emerged as a promising technique to fulfill the need for a noninvasive assessment of myocardial fibrosis through the use of Gd-based contrast agents and the quantification of the longitudinal relaxation time T1. This paper reviews the current use of T1 mapping for the assessment of myocardial fibrosis, with particular focus on imaging techniques and their validation.

TaalEngels
Artikelnummer9260
Pagina's1-12
Aantal pagina's12
TijdschriftCurrent Cardiovascular Imaging Reports
Volume7
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 2014

Vingerafdruk

Fibrosis
Magnetic Resonance Imaging
Gold
Contrast Media
Heart Diseases
Anatomy
Cardiovascular Diseases
Therapeutics

Trefwoorden

    Citeer dit

    @article{23a4393fd8004b859afced3ddf90bf17,
    title = "Contrast-enhanced T1-mapping MRI for the assessment of myocardial fibrosis",
    abstract = "Fibrosis is a common feature of heart disease and is associated with adverse cardiac remodeling and poor clinical outcome. Because of the lack of routine noninvasive patient-specific tissue characterization tools, the development of new treatment strategies for cardiovascular disease specifically targeting undesired fibrosis in the myocardial wall is slow. Cardiovascular magnetic resonance imaging has developed into the gold-standard tool to assess various aspects of myocardial anatomy and function. In recent years, magnetic resonance imaging has also emerged as a promising technique to fulfill the need for a noninvasive assessment of myocardial fibrosis through the use of Gd-based contrast agents and the quantification of the longitudinal relaxation time T1. This paper reviews the current use of T1 mapping for the assessment of myocardial fibrosis, with particular focus on imaging techniques and their validation.",
    keywords = "Cardiovascular disease, Coronary heart disease, Fibrosis, Gd contrast agent, Magnetic resonance imaging, Myocardial infarction",
    author = "{de Graaf}, W.L. and K. Vandoorne and F. Arslan and K. Nicolaij and G.J. Strijkers",
    year = "2014",
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    issn = "1941-9066",
    publisher = "Current Medicine Group",
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    }

    Contrast-enhanced T1-mapping MRI for the assessment of myocardial fibrosis. / de Graaf, W.L.; Vandoorne, K.; Arslan, F.; Nicolaij, K.; Strijkers, G.J.

    In: Current Cardiovascular Imaging Reports, Vol. 7, Nr. 4, 9260, 2014, blz. 1-12.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

    TY - JOUR

    T1 - Contrast-enhanced T1-mapping MRI for the assessment of myocardial fibrosis

    AU - de Graaf,W.L.

    AU - Vandoorne,K.

    AU - Arslan,F.

    AU - Nicolaij,K.

    AU - Strijkers,G.J.

    PY - 2014

    Y1 - 2014

    N2 - Fibrosis is a common feature of heart disease and is associated with adverse cardiac remodeling and poor clinical outcome. Because of the lack of routine noninvasive patient-specific tissue characterization tools, the development of new treatment strategies for cardiovascular disease specifically targeting undesired fibrosis in the myocardial wall is slow. Cardiovascular magnetic resonance imaging has developed into the gold-standard tool to assess various aspects of myocardial anatomy and function. In recent years, magnetic resonance imaging has also emerged as a promising technique to fulfill the need for a noninvasive assessment of myocardial fibrosis through the use of Gd-based contrast agents and the quantification of the longitudinal relaxation time T1. This paper reviews the current use of T1 mapping for the assessment of myocardial fibrosis, with particular focus on imaging techniques and their validation.

    AB - Fibrosis is a common feature of heart disease and is associated with adverse cardiac remodeling and poor clinical outcome. Because of the lack of routine noninvasive patient-specific tissue characterization tools, the development of new treatment strategies for cardiovascular disease specifically targeting undesired fibrosis in the myocardial wall is slow. Cardiovascular magnetic resonance imaging has developed into the gold-standard tool to assess various aspects of myocardial anatomy and function. In recent years, magnetic resonance imaging has also emerged as a promising technique to fulfill the need for a noninvasive assessment of myocardial fibrosis through the use of Gd-based contrast agents and the quantification of the longitudinal relaxation time T1. This paper reviews the current use of T1 mapping for the assessment of myocardial fibrosis, with particular focus on imaging techniques and their validation.

    KW - Cardiovascular disease

    KW - Coronary heart disease

    KW - Fibrosis

    KW - Gd contrast agent

    KW - Magnetic resonance imaging

    KW - Myocardial infarction

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    DO - 10.1007/s12410-014-9260-6

    M3 - Review article

    VL - 7

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    EP - 12

    JO - Current Cardiovascular Imaging Reports

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