Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: a two-year follow-up HRpQCT study

J.J.A. de Jong, J.J.C. Arts, P.C. Willems, S.G.P. Bours, J.P.A. Bons, P.P.C.A. Menheere, B. van Rietbergen, P.P.M.M. Geusens, J.P.W. van den Bergh

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT). The contra-lateral distal radius of 15 postmenopausal women (mean age 64±8years) with a distal radius fracture treated by cast immobilization was scanned by HRpQCT at baseline, 3months and 2year post-fracture. BMD and cortical and trabecular micro-architecture were measured and biomechanical parameters were estimated using micro finite element analysis (μFEA). Additionally, markers of bone resorption and formation were measured at each visit. Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction. Two year post-fracture, a significant decrease from baseline was found in cortical BMD (-4.2%, p<0.001), failure load (-6.1%, p=0.001), stiffness in compression (-5.7%, p=0.003) and bending (-6.4%, p=0.008), and bone formation (-47.6%, p=0.010). No significant changes from baseline were observed in total and trabecular BMD, nor in cortical or trabecular micro-architecture and neither in bone resorption. Results were similar between patients with or without adequate anti-osteoporosis drug treatment. We found a significant decline in BMD in the cortical but not the trabecular region, and a reduction in bone strength and stiffness at the contra-lateral side two years after a distal radius fracture. These changes exceeded the changes that may be expected due to aging, even in the presence of adequate anti-osteoporosis treatment.

TaalEngels
Pagina's245-251
Aantal pagina's7
TijdschriftBone
Volume101
Vroegere onlinedatum11 mei 2017
DOI's
StatusGepubliceerd - 1 aug 2017

Vingerafdruk

Radius Fractures
Bone Density
Tomography
Bone and Bones
Bone Resorption
Osteogenesis
Osteoporosis
Finite Element Analysis
Bone Remodeling
Immobilization
Therapeutics
Pharmaceutical Preparations

Trefwoorden

    Citeer dit

    de Jong, J. J. A., Arts, J. J. C., Willems, P. C., Bours, S. G. P., Bons, J. P. A., Menheere, P. P. C. A., ... van den Bergh, J. P. W. (2017). Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: a two-year follow-up HRpQCT study. Bone, 101, 245-251. DOI: 10.1016/j.bone.2017.05.011
    de Jong, J.J.A. ; Arts, J.J.C. ; Willems, P.C. ; Bours, S.G.P. ; Bons, J.P.A. ; Menheere, P.P.C.A. ; van Rietbergen, B. ; Geusens, P.P.M.M. ; van den Bergh, J.P.W./ Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture : a two-year follow-up HRpQCT study. In: Bone. 2017 ; Vol. 101. blz. 245-251
    @article{6e3e65c3d10641cf9b2d329b105147e0,
    title = "Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: a two-year follow-up HRpQCT study",
    abstract = "Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT). The contra-lateral distal radius of 15 postmenopausal women (mean age 64±8years) with a distal radius fracture treated by cast immobilization was scanned by HRpQCT at baseline, 3months and 2year post-fracture. BMD and cortical and trabecular micro-architecture were measured and biomechanical parameters were estimated using micro finite element analysis (μFEA). Additionally, markers of bone resorption and formation were measured at each visit. Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction. Two year post-fracture, a significant decrease from baseline was found in cortical BMD (-4.2{\%}, p<0.001), failure load (-6.1{\%}, p=0.001), stiffness in compression (-5.7{\%}, p=0.003) and bending (-6.4{\%}, p=0.008), and bone formation (-47.6{\%}, p=0.010). No significant changes from baseline were observed in total and trabecular BMD, nor in cortical or trabecular micro-architecture and neither in bone resorption. Results were similar between patients with or without adequate anti-osteoporosis drug treatment. We found a significant decline in BMD in the cortical but not the trabecular region, and a reduction in bone strength and stiffness at the contra-lateral side two years after a distal radius fracture. These changes exceeded the changes that may be expected due to aging, even in the presence of adequate anti-osteoporosis treatment.",
    keywords = "Journal Article",
    author = "{de Jong}, J.J.A. and J.J.C. Arts and P.C. Willems and S.G.P. Bours and J.P.A. Bons and P.P.C.A. Menheere and {van Rietbergen}, B. and P.P.M.M. Geusens and {van den Bergh}, J.P.W.",
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    de Jong, JJA, Arts, JJC, Willems, PC, Bours, SGP, Bons, JPA, Menheere, PPCA, van Rietbergen, B, Geusens, PPMM & van den Bergh, JPW 2017, 'Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: a two-year follow-up HRpQCT study' Bone, vol. 101, blz. 245-251. DOI: 10.1016/j.bone.2017.05.011

    Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture : a two-year follow-up HRpQCT study. / de Jong, J.J.A.; Arts, J.J.C.; Willems, P.C.; Bours, S.G.P.; Bons, J.P.A.; Menheere, P.P.C.A.; van Rietbergen, B.; Geusens, P.P.M.M.; van den Bergh, J.P.W.

    In: Bone, Vol. 101, 01.08.2017, blz. 245-251.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    TY - JOUR

    T1 - Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture

    T2 - Bone

    AU - de Jong,J.J.A.

    AU - Arts,J.J.C.

    AU - Willems,P.C.

    AU - Bours,S.G.P.

    AU - Bons,J.P.A.

    AU - Menheere,P.P.C.A.

    AU - van Rietbergen,B.

    AU - Geusens,P.P.M.M.

    AU - van den Bergh,J.P.W.

    N1 - Copyright © 2016. Published by Elsevier Inc.

    PY - 2017/8/1

    Y1 - 2017/8/1

    N2 - Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT). The contra-lateral distal radius of 15 postmenopausal women (mean age 64±8years) with a distal radius fracture treated by cast immobilization was scanned by HRpQCT at baseline, 3months and 2year post-fracture. BMD and cortical and trabecular micro-architecture were measured and biomechanical parameters were estimated using micro finite element analysis (μFEA). Additionally, markers of bone resorption and formation were measured at each visit. Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction. Two year post-fracture, a significant decrease from baseline was found in cortical BMD (-4.2%, p<0.001), failure load (-6.1%, p=0.001), stiffness in compression (-5.7%, p=0.003) and bending (-6.4%, p=0.008), and bone formation (-47.6%, p=0.010). No significant changes from baseline were observed in total and trabecular BMD, nor in cortical or trabecular micro-architecture and neither in bone resorption. Results were similar between patients with or without adequate anti-osteoporosis drug treatment. We found a significant decline in BMD in the cortical but not the trabecular region, and a reduction in bone strength and stiffness at the contra-lateral side two years after a distal radius fracture. These changes exceeded the changes that may be expected due to aging, even in the presence of adequate anti-osteoporosis treatment.

    AB - Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT). The contra-lateral distal radius of 15 postmenopausal women (mean age 64±8years) with a distal radius fracture treated by cast immobilization was scanned by HRpQCT at baseline, 3months and 2year post-fracture. BMD and cortical and trabecular micro-architecture were measured and biomechanical parameters were estimated using micro finite element analysis (μFEA). Additionally, markers of bone resorption and formation were measured at each visit. Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction. Two year post-fracture, a significant decrease from baseline was found in cortical BMD (-4.2%, p<0.001), failure load (-6.1%, p=0.001), stiffness in compression (-5.7%, p=0.003) and bending (-6.4%, p=0.008), and bone formation (-47.6%, p=0.010). No significant changes from baseline were observed in total and trabecular BMD, nor in cortical or trabecular micro-architecture and neither in bone resorption. Results were similar between patients with or without adequate anti-osteoporosis drug treatment. We found a significant decline in BMD in the cortical but not the trabecular region, and a reduction in bone strength and stiffness at the contra-lateral side two years after a distal radius fracture. These changes exceeded the changes that may be expected due to aging, even in the presence of adequate anti-osteoporosis treatment.

    KW - Journal Article

    U2 - 10.1016/j.bone.2017.05.011

    DO - 10.1016/j.bone.2017.05.011

    M3 - Article

    VL - 101

    SP - 245

    EP - 251

    JO - Bone

    JF - Bone

    SN - 8756-3282

    ER -

    de Jong JJA, Arts JJC, Willems PC, Bours SGP, Bons JPA, Menheere PPCA et al. Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: a two-year follow-up HRpQCT study. Bone. 2017 aug 1;101:245-251. Beschikbaar vanaf, DOI: 10.1016/j.bone.2017.05.011