Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R.L.J. Bloemendal; Mathilde A.C.H. Janssen; Jan C.M. van Hest; Floris P.J.T. Rutjes

doi:10.1039/d0re00087f

Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R.L.J. Bloemendal, Mathilde A.C.H. Janssen, Jan C.M. van Hest (Corresponding author), Floris P.J.T. Rutjes (Corresponding author)

Bio-Organic Chemistry

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

14 Citaten (Scopus)

Samenvatting

During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

Originele taal-2	Engels
Pagina's (van-tot)	1186-1197
Aantal pagina's	12
Tijdschrift	Reaction Chemistry and Engineering
Volume	5
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1039/d0re00087f
Status	Gepubliceerd - 1 jul 2020

Toegang tot document

10.1039/d0re00087f

Vingerafdruk Duik in de onderzoeksthema's van 'Continuous one-flow multi-step synthesis of active pharmaceutical ingredients'. Samen vormen ze een unieke vingerafdruk.

Citeer dit

@article{aad6a06c50f64d0d9d92651a42602ebe,

title = "Continuous one-flow multi-step synthesis of active pharmaceutical ingredients",

abstract = "During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.",

author = "Bloemendal, {Victor R.L.J.} and Janssen, {Mathilde A.C.H.} and {van Hest}, {Jan C.M.} and Rutjes, {Floris P.J.T.}",

year = "2020",

month = jul,

day = "1",

doi = "10.1039/d0re00087f",

language = "English",

volume = "5",

pages = "1186--1197",

journal = "Reaction Chemistry and Engineering",

issn = "2058-9883",

publisher = "Royal Society of Chemistry",

number = "7",

}

Continuous one-flow multi-step synthesis of active pharmaceutical ingredients. / Bloemendal, Victor R.L.J.; Janssen, Mathilde A.C.H.; van Hest, Jan C.M. (Corresponding author); Rutjes, Floris P.J.T. (Corresponding author).

In: Reaction Chemistry and Engineering, Vol. 5, Nr. 7, 01.07.2020, blz. 1186-1197.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

TY - JOUR

T1 - Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

AU - Bloemendal, Victor R.L.J.

AU - Janssen, Mathilde A.C.H.

AU - van Hest, Jan C.M.

AU - Rutjes, Floris P.J.T.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

AB - During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

UR - http://www.scopus.com/inward/record.url?scp=85089008478&partnerID=8YFLogxK

U2 - 10.1039/d0re00087f

DO - 10.1039/d0re00087f

M3 - Review article

AN - SCOPUS:85089008478

VL - 5

SP - 1186

EP - 1197

JO - Reaction Chemistry and Engineering

JF - Reaction Chemistry and Engineering

SN - 2058-9883

IS - 7

ER -