Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia

Michiel Kroesen, Hendrik T. Mulder, Jeanette M.L. van Holthe, Aleida A. Aangeenbrug, Jan Willem M. Mens, Helena C. van Doorn, Margarethus M. Paulides, Esther Oomen-de Hoop, Rene M. Vernhout, Ludy C. Lutgens, Gerard C. van Rhoon, Martine Franckena (Corresponding author)

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Uittreksel

Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC. Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT). Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan–Meier analyses. Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis. Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed.

TaalEngels
Pagina's150-158
Aantal pagina's9
TijdschriftRadiotherapy and Oncology
Volume140
DOI's
StatusGepubliceerd - 1 nov 2019

Vingerafdruk

Art Therapy
Fever
Radiotherapy
Hot Temperature
Carcinoma
Brachytherapy
Survival
Kaplan-Meier Estimate
Disease-Free Survival
Histology
Multivariate Analysis
Radiation

Trefwoorden

    Citeer dit

    Kroesen, M., Mulder, H. T., van Holthe, J. M. L., Aangeenbrug, A. A., Mens, J. W. M., van Doorn, H. C., ... Franckena, M. (2019). Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia. Radiotherapy and Oncology, 140, 150-158. DOI: 10.1016/j.radonc.2019.06.021
    Kroesen, Michiel ; Mulder, Hendrik T. ; van Holthe, Jeanette M.L. ; Aangeenbrug, Aleida A. ; Mens, Jan Willem M. ; van Doorn, Helena C. ; Paulides, Margarethus M. ; Oomen-de Hoop, Esther ; Vernhout, Rene M. ; Lutgens, Ludy C. ; van Rhoon, Gerard C. ; Franckena, Martine. / Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia. In: Radiotherapy and Oncology. 2019 ; Vol. 140. blz. 150-158
    @article{8b1a373c4b624da093ba0ce31da9335e,
    title = "Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia",
    abstract = "Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC. Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT). Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan–Meier analyses. Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis. Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed.",
    keywords = "CEM43T90, Cervical cancer, Hyperthermia, Image guided brachytherapy, Thermal dose, Treatment outcome, Trise",
    author = "Michiel Kroesen and Mulder, {Hendrik T.} and {van Holthe}, {Jeanette M.L.} and Aangeenbrug, {Aleida A.} and Mens, {Jan Willem M.} and {van Doorn}, {Helena C.} and Paulides, {Margarethus M.} and {Oomen-de Hoop}, Esther and Vernhout, {Rene M.} and Lutgens, {Ludy C.} and {van Rhoon}, {Gerard C.} and Martine Franckena",
    year = "2019",
    month = "11",
    day = "1",
    doi = "10.1016/j.radonc.2019.06.021",
    language = "English",
    volume = "140",
    pages = "150--158",
    journal = "Radiotherapy and Oncology",
    issn = "0167-8140",
    publisher = "Elsevier Ireland Ltd",

    }

    Kroesen, M, Mulder, HT, van Holthe, JML, Aangeenbrug, AA, Mens, JWM, van Doorn, HC, Paulides, MM, Oomen-de Hoop, E, Vernhout, RM, Lutgens, LC, van Rhoon, GC & Franckena, M 2019, 'Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia' Radiotherapy and Oncology, vol. 140, blz. 150-158. DOI: 10.1016/j.radonc.2019.06.021

    Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia. / Kroesen, Michiel; Mulder, Hendrik T.; van Holthe, Jeanette M.L.; Aangeenbrug, Aleida A.; Mens, Jan Willem M.; van Doorn, Helena C.; Paulides, Margarethus M.; Oomen-de Hoop, Esther; Vernhout, Rene M.; Lutgens, Ludy C.; van Rhoon, Gerard C.; Franckena, Martine (Corresponding author).

    In: Radiotherapy and Oncology, Vol. 140, 01.11.2019, blz. 150-158.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    TY - JOUR

    T1 - Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia

    AU - Kroesen,Michiel

    AU - Mulder,Hendrik T.

    AU - van Holthe,Jeanette M.L.

    AU - Aangeenbrug,Aleida A.

    AU - Mens,Jan Willem M.

    AU - van Doorn,Helena C.

    AU - Paulides,Margarethus M.

    AU - Oomen-de Hoop,Esther

    AU - Vernhout,Rene M.

    AU - Lutgens,Ludy C.

    AU - van Rhoon,Gerard C.

    AU - Franckena,Martine

    PY - 2019/11/1

    Y1 - 2019/11/1

    N2 - Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC. Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT). Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan–Meier analyses. Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis. Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed.

    AB - Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniques were introduced resulting in improved LC. Aim: To validate the effect of thermal dose in a more recent cohort of patients treated with modern radiotherapy techniques, including image guided brachytherapy (IGBT). Methods: We analyzed primary cervical carcinoma patients treated with a combination of radiotherapy and deep hyperthermia between 2005 and 2016 at our institute. Data on patient, tumor and treatment were collected including the thermal dose parameters TRISE and CEM43T90. Follow-up data on LC, disease free survival, DSS, OS as well as late toxicity data were collected. Data were analyzed using the Cox proportional hazard and Kaplan–Meier analyses. Results: 227 patients were included. In multivariate analysis, histology, FIGO stage, lymphadenopathy, TRISE, CEM43T90 and IGBT had a significant effect on LC. In the patients treated with IGBT, the thermal dose parameter TRISE remained to have a significant effect on LC in univariate analysis. Conclusions: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed.

    KW - CEM43T90

    KW - Cervical cancer

    KW - Hyperthermia

    KW - Image guided brachytherapy

    KW - Thermal dose

    KW - Treatment outcome

    KW - Trise

    UR - http://www.scopus.com/inward/record.url?scp=85068583605&partnerID=8YFLogxK

    U2 - 10.1016/j.radonc.2019.06.021

    DO - 10.1016/j.radonc.2019.06.021

    M3 - Article

    VL - 140

    SP - 150

    EP - 158

    JO - Radiotherapy and Oncology

    T2 - Radiotherapy and Oncology

    JF - Radiotherapy and Oncology

    SN - 0167-8140

    ER -