Computational modeling of cell orientation in 3D micro-constructs

Christine Obbink-Huizer, Cees W.J. Oomens, Sandra Loerakker, Jasper Foolen, Carlijn V.C. Bouten, Frank P.T. Baaijens

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

In many tissue engineering applications it is essential to understand how cells orient under the influence of their mechanical environment. In vitro engineered models are used to investigate the orientation of F-actin stress fibers inside cells. One such in vitro model [1] consists of a mixture of cells, collagen and matrigel, that is constrained by an array of silicone posts (Figure 1). We have recently developed a computational model to describe the orientation of stress fibers in response to their mechanical environment [2]. In the present study, this computational model is extended to 3D and used to simulate cell behavior in the mentioned in vitro model. This improves our understanding of how stress fibers orient in response to the mechanical environment and aids in optimizing the use of the in vitro model.
Originele taal-2Engels
TitelASME 2013 Summer Bioengineering Conference, SBC 2013
Aantal pagina's2
Volume1 A
DOI's
StatusGepubliceerd - 1 dec 2013
EvenementASME 2013 Summer Bioengineering Conference (SBC 2013) - Sunriver, Verenigde Staten van Amerika
Duur: 26 jun 201329 jun 2013
http://www.asmeconferences.org/SBC2013/

Congres

CongresASME 2013 Summer Bioengineering Conference (SBC 2013)
Verkorte titelSBC 2013
LandVerenigde Staten van Amerika
StadSunriver
Periode26/06/1329/06/13
AnderASME 2013 Summer Bioengineering Conference (SBC 2013)
Internet adres

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