Collective cell durotaxis emerges from long-range intercellular force transmission

Raimon Sunyer, Vito Conte, Jorge Escribano, Alberto Elosegui-Artola, Anna Labernadie, Léo Valon, Daniel Navajas, José Manuel García-Aznar, José J. Muñoz, Pere Roca-Cusachs, Xavier Trepat

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

228 Citaten (Scopus)

Samenvatting

The ability of cells to follow gradients of extracellular matrix stiffness-durotaxis-has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion.

Originele taal-2Engels
Pagina's (van-tot)1157-1161
Aantal pagina's5
TijdschriftScience
Volume353
Nummer van het tijdschrift6304
DOI's
StatusGepubliceerd - 9 sep 2016
Extern gepubliceerdJa

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