Chemical Intensification in flow chemistry through harsh reaction conditions and new reaction design

Chemical intensification aims to enhance chemical processes by employing harsh reaction conditions, such as high temperatures, high pressures, solvent effects, high concentration of the reactants, handling of hazardous compounds and novel chemical transformations. The process design intensification field is directed toward the complete production design aspect of chemical manufacturing. It intends to simplify and integrate the different reaction and purification steps of a chemical reaction sequence in a single streamlined and continuous-flow process. Although the concept is relatively new, novel process windows have had already a significant impact on flow chemistry applications, as well as on the process engineering aspect. This chapter discusses each aspect of novel process windows and provides several literature examples. It concludes by providing two verified in-house laboratory experiments.