Chelating amphiphilic polymers

Holger Gruell; Anke de Vries; Sander Langereis; Johan Lub; E.M.G. Aussems-Custers

Chelating amphiphilic polymers

Holger Gruell (Uitvinder), Anke de Vries (Uitvinder), Sander Langereis (Uitvinder), Johan Lub (Uitvinder), E.M.G. Aussems-Custers (Uitvinder)

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Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

Originele taal-2	Engels
Octrooinummer	WO2010029500
IPC	A61K 49/ 00 A I
Prioriteitsdatum	9/09/08
Status	Gepubliceerd - 18 mrt. 2010

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WO2010029500A1Definitieve gepubliceerde versie, 2,1 MB

https://nl.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=nl_NL&FT=D&date=20100318&CC=WO&NR=2010029500A1&KC=A1#

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title = "Chelating amphiphilic polymers",

abstract = "Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.",

author = "Holger Gruell and {de Vries}, Anke and Sander Langereis and Johan Lub and E.M.G. Aussems-Custers",

year = "2010",

month = mar,

day = "18",

language = "English",

type = "Patent",

note = "WO2010029500; A61K 49/ 00 A I",

}

TY - PAT

T1 - Chelating amphiphilic polymers

AU - Gruell, Holger

AU - de Vries, Anke

AU - Langereis, Sander

AU - Lub, Johan

AU - Aussems-Custers, E.M.G.

PY - 2010/3/18

Y1 - 2010/3/18

N2 - Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

AB - Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

M3 - Patent publication

M1 - WO2010029500

ER -

Chelating amphiphilic polymers

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