Characterizing the effect of demographics, cardiorespiratory factors, and inter-subject variation on maternal heart rate variability in pregnancy with statistical modeling: a retrospective observational analysis

M. Bester (Corresponding author), R. Joshi, A. Linders, M. Mischi, J.O.E.H. van Laar, R. Vullings

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

4 Citaten (Scopus)
24 Downloads (Pure)

Samenvatting

Pregnancy complications are associated with insufficient adaptation of the maternal autonomic nervous system to the physiological demands of pregnancy. Consequently, assessing maternal heart rate variability (mHRV)—which reflects autonomic regulation—is a promising tool for detecting early deterioration in maternal health. However, before mHRV can be used to screen for complications, an understanding of the factors influencing mHRV during healthy pregnancy is needed. In this retrospective observational study, we develop regression models to unravel the effects of maternal demographics (age, body mass index (BMI), gestational age (GA), and parity), cardiorespiratory factors (heart rate and breathing rate), and inter-subject variation on mHRV. We develop these models using two datasets which are comprised of, respectively, single measurements in 290 healthy pregnant women and repeated measurements (median = 8) in 29 women with healthy pregnancies. Our most consequential finding is that between one-third and two-thirds of the variation in mHRV can be attributed to inter-subject variability. Additionally, median heart rate dominantly affects mHRV (p < 0.001), while BMI and parity have no effect. Moreover, we found that median breathing rate, age, and GA all impact mHRV (p < 0.05). These results suggest that personalized, long-term monitoring would be necessary for using mHRV for obstetric screening.

Originele taal-2Engels
Artikelnummer19305
Aantal pagina's9
TijdschriftScientific Reports
Volume12
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 11 nov. 2022

Bibliografische nota

Funding Information:
This research was performed in the framework of e/MTIC. The research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Vingerafdruk

Duik in de onderzoeksthema's van 'Characterizing the effect of demographics, cardiorespiratory factors, and inter-subject variation on maternal heart rate variability in pregnancy with statistical modeling: a retrospective observational analysis'. Samen vormen ze een unieke vingerafdruk.

Citeer dit