Catheter-induced errors in pressure measurements in vessels: An in-vitro and numerical study

A. De Vecchi, R.E. Clough, N.R. Gaddum, M.C.M. Rutten, P. Lamata, T. Schaeffter, D.A. Nordsletten, N.P. Smith

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

22 Citaten (Scopus)
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Accurate measurement of blood pressure is important because it is a biomarker for cardiovascular disease. Diagnostic catheterization is routinely used for pressure acquisition in vessels despite being subject to significant measurement errors. To investigate these errors, this study compares pressure measurement using two different techniques in vitro and numerical simulations. Pressure was acquired in a pulsatile flow phantom using a 6F fluid-filled catheter and a 0.014'' pressure wire, which is considered the current gold standard. Numerical simulations of the experimental set-up with and without a catheter were also performed. Despite the low catheter-to-vessel radius ratio, the catheter traces showed a 24% peak systolic pressure overestimation compared to the wire. The numerical models replicated this difference and indicated the cause for overestimation was the increased flow resistance due to the presence of the catheter. Further, the higher frequency pressure oscillations observed in the wire and numerical data were absent in the catheter, resulting in an overestimation of the pulse wave velocity with the latter modality. These results show that catheter geometry produces significant measurement bias in both the peak pressure and the waveform shape even with radius ratios considered acceptable in clinical practice. The wire allows for more accurate pressure quantification, in agreement with the numerical model without a catheter.

Originele taal-2Engels
Pagina's (van-tot)1844-1850
Aantal pagina's7
TijdschriftIEEE Transactions on Biomedical Engineering
Nummer van het tijdschrift6
StatusGepubliceerd - 2014

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