Cascade reactions in multicompartmentalized polymersomes

R.J.R.W. Peters, M. Marguet, S. Marais, M.W. Fraaije, J.C.M. van Hest, S. Lecommandoux

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

254 Citaten (Scopus)
2 Downloads (Pure)

Samenvatting

Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments. Mimicking cells: Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanylaminoethyl) thiophene) (PS-b-PIAT) nanoreactors have been encapsulated together with free enzymes and substrates in a larger polymersome to form a multicompartmentalized structure, which shows structural resemblance to a cell and its organelles (see picture). An original cofactor-dependent three-enzyme cascade reaction, with either compatible or incompatible enzymes, takes place across multiple compartments.

Originele taal-2Engels
Pagina's (van-tot)146-150
Aantal pagina's5
TijdschriftAngewandte Chemie - International Edition
Volume53
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 3 jan 2014
Extern gepubliceerdJa

Vingerafdruk Duik in de onderzoeksthema's van 'Cascade reactions in multicompartmentalized polymersomes'. Samen vormen ze een unieke vingerafdruk.

  • Citeer dit

    Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., van Hest, J. C. M., & Lecommandoux, S. (2014). Cascade reactions in multicompartmentalized polymersomes. Angewandte Chemie - International Edition, 53(1), 146-150. https://doi.org/10.1002/anie.201308141