Samenvatting
The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous “ordinary–extraordinary” phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.
| Originele taal-2 | Engels |
|---|---|
| Artikelnummer | 1702888 |
| Aantal pagina's | 12 |
| Tijdschrift | Advanced Materials |
| Volume | 29 |
| Nummer van het tijdschrift | 39 |
| DOI's | |
| Status | Gepubliceerd - 18 okt 2017 |
Financiering
The authors acknowledge the Valencian Institute of Pathology for the histology experiments, the technical staff at ILL and ISIS for the support on SANS experiments, David Gil for cryo-TEM and 3D tomographic reconstruction assistance, Stuart P. Atkinson for English editing, Beatriu Escuder for support on TEM experiments and discussion, and Biond Science & Communication for graphical designs. The authors want to thank the Spanish Ministry of Economy and Competitiveness (SAF2013-44848-R, SAF2016-80427-R, PTQ-13-06465) and the European Research Council (Grant ERC-CoG-2014-648831 MyNano) for financial support. Part of the equipment employed in this work has been funded by Generalitat Valenciana and co-financed with FEDER funds (PO FEDER of Comunitat Valenciana 2014-2020). A.D.-C., V.J.N., and M.J.V. designed the experiments and paper outline. A.D.-C. and V.J.N. performed the synthetic and characterization experiments. A.N.-P. and A.P. performed SANS experiments and analysis. N.F.-G. and L.A. performed FRET and STORM experiments. A.D.-C. performed in vitro experiments. A.D.-C., J.J.A.-C., and A.A. performed the in vivo experiments. A.D.-C., V.J.N, A.N.-P., A.P., N.F.-G., L.A., J.J.A.-C., A.A., and M.J.V. discussed and analyzed the data. A.D.-C. and V.J.N. wrote and revised the paper. A.D.-C., V.J.N., L.A., and M.J.V. commented and revised the paper. A.D.-C., V.J.N., and M.J.V. led or supervised this project.
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