Cancer stem cell migration in an oxygen gradient characterized using a microfluidic device

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Samenvatting

Recently, cancer stem cells (CSCs) have been proposed as the source of metastases, yet only little is known about the migration of CSCs in the tumor microenvironment (TME). The presence of oxygen gradients in the TME has been linked to directional migration of breast cancer cells. Here, we present a method to study the effect of oxygen gradients on breast CSC migration, using a PDMS microfluidic chip. We demonstrate our capability to perform single cell tracking in a stable gradient. Surprisingly, our results indicate a migration direction opposite to the direction reported in a previous study.

Originele taal-2Engels
Titel22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
UitgeverijChemical and Biological Microsystems Society
Pagina's1517-1520
Aantal pagina's4
Volume3
ISBN van elektronische versie9781510897571
StatusGepubliceerd - 2018
Evenement22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duur: 11 nov 201815 nov 2018

Congres

Congres22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
LandTaiwan
StadKaohsiung
Periode11/11/1815/11/18

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