Cancer intravasation-on-a-chip : a LEGO house for tumors!

H. Eslami Amirabadi, Sh. Sahebali, A.L.W. Miggiels, J.Ph. Frimat, R. Luttge, J. den Toonder

Onderzoeksoutput: Bijdrage aan congresPosterAcademic

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The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:
•more control on the biochemical content,
•less human error by automating the experiments,
•more complex designs,
•and less ethical issues, it is a LEGO house!
The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.
Originele taal-2Engels
StatusGepubliceerd - nov 2015

Vingerafdruk

Neoplasms
Microfluidics
Extracellular Matrix
Ethics
Blood Vessels

Citeer dit

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abstract = "The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:•more control on the biochemical content,•less human error by automating the experiments,•more complex designs,•and less ethical issues, it is a LEGO house!The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.",
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Cancer intravasation-on-a-chip : a LEGO house for tumors! / Eslami Amirabadi, H.; Sahebali, Sh.; Miggiels, A.L.W.; Frimat, J.Ph.; Luttge, R.; den Toonder, J.

2015.

Onderzoeksoutput: Bijdrage aan congresPosterAcademic

TY - CONF

T1 - Cancer intravasation-on-a-chip : a LEGO house for tumors!

AU - Eslami Amirabadi, H.

AU - Sahebali, Sh.

AU - Miggiels, A.L.W.

AU - Frimat, J.Ph.

AU - Luttge, R.

AU - den Toonder, J.

PY - 2015/11

Y1 - 2015/11

N2 - The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:•more control on the biochemical content,•less human error by automating the experiments,•more complex designs,•and less ethical issues, it is a LEGO house!The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.

AB - The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:•more control on the biochemical content,•less human error by automating the experiments,•more complex designs,•and less ethical issues, it is a LEGO house!The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.

M3 - Poster

ER -