Building Kidney Exchange Programmes in Europe: an overview of exchange practice and activities

Peter Biro (Corresponding author), Bernadette Haase-Kromwijk, Tommy Andersson, Eyolfur Ásgeirsson, Tatiana Baltesová, Ioannis Boletis, Catarina Bolotinha, Gregor Bond, Georg Böhmig, Lisa Burnapp, Katarína Cechlárová, Paolo Di Caccio, Jiri Fronek, Karine Hadaya, Aline Hemke, Christian Jacquelinet, Rachel Johnson, Rafal Kieszek, Dirk Kuypers, Ruthanne Leisman & 10 andere Marie-Alice Macher, David Manlove, Georgia Menoudakou, Mikko Salonen, Bart Smeulders, Vito Sparacino, F.C.R. Spieksma, Maria de la Oliva Valentín Muñoz, Nic Wilson, Joris van de Klundert

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

BACKGROUND:
Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.

METHODS:
Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts.

RESULTS:
The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8% of their countries' living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe.

CONCLUSIONS:
Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
TaalEngels
Pagina's1514-1522
Aantal pagina's9
TijdschriftTransplantation
Volume103
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - 1 jul 2019

Vingerafdruk

Kidney
Living Donors
Practice Guidelines
Tissue Donors
Scandinavian and Nordic Countries
Transplants
Kidney Diseases
Licensure
Health Care Costs
Reproduction

Citeer dit

Biro, P., Haase-Kromwijk, B., Andersson, T., Ásgeirsson, E., Baltesová, T., Boletis, I., ... van de Klundert, J. (2019). Building Kidney Exchange Programmes in Europe: an overview of exchange practice and activities. Transplantation, 103(7), 1514-1522. DOI: 10.1097/TP.0000000000002432
Biro, Peter ; Haase-Kromwijk, Bernadette ; Andersson, Tommy ; Ásgeirsson, Eyolfur ; Baltesová, Tatiana ; Boletis, Ioannis ; Bolotinha, Catarina ; Bond, Gregor ; Böhmig, Georg ; Burnapp, Lisa ; Cechlárová, Katarína ; Di Caccio, Paolo ; Fronek, Jiri ; Hadaya, Karine ; Hemke, Aline ; Jacquelinet, Christian ; Johnson, Rachel ; Kieszek, Rafal ; Kuypers, Dirk ; Leisman, Ruthanne ; Macher, Marie-Alice ; Manlove, David ; Menoudakou, Georgia ; Salonen, Mikko ; Smeulders, Bart ; Sparacino, Vito ; Spieksma, F.C.R. ; de la Oliva Valentín Muñoz, Maria ; Wilson, Nic ; van de Klundert, Joris. / Building Kidney Exchange Programmes in Europe : an overview of exchange practice and activities. In: Transplantation. 2019 ; Vol. 103, Nr. 7. blz. 1514-1522
@article{a0231b821602449b937b871ad4b6838a,
title = "Building Kidney Exchange Programmes in Europe: an overview of exchange practice and activities",
abstract = "BACKGROUND:Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.METHODS:Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts.RESULTS:The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8{\%} of their countries' living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe.CONCLUSIONS:Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
author = "Peter Biro and Bernadette Haase-Kromwijk and Tommy Andersson and Eyolfur {\'A}sgeirsson and Tatiana Baltesov{\'a} and Ioannis Boletis and Catarina Bolotinha and Gregor Bond and Georg B{\"o}hmig and Lisa Burnapp and Katar{\'i}na Cechl{\'a}rov{\'a} and {Di Caccio}, Paolo and Jiri Fronek and Karine Hadaya and Aline Hemke and Christian Jacquelinet and Rachel Johnson and Rafal Kieszek and Dirk Kuypers and Ruthanne Leisman and Marie-Alice Macher and David Manlove and Georgia Menoudakou and Mikko Salonen and Bart Smeulders and Vito Sparacino and F.C.R. Spieksma and {de la Oliva Valent{\'i}n Mu{\~n}oz}, Maria and Nic Wilson and {van de Klundert}, Joris",
year = "2019",
month = "7",
day = "1",
doi = "10.1097/TP.0000000000002432",
language = "English",
volume = "103",
pages = "1514--1522",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "7",

}

Biro, P, Haase-Kromwijk, B, Andersson, T, Ásgeirsson, E, Baltesová, T, Boletis, I, Bolotinha, C, Bond, G, Böhmig, G, Burnapp, L, Cechlárová, K, Di Caccio, P, Fronek, J, Hadaya, K, Hemke, A, Jacquelinet, C, Johnson, R, Kieszek, R, Kuypers, D, Leisman, R, Macher, M-A, Manlove, D, Menoudakou, G, Salonen, M, Smeulders, B, Sparacino, V, Spieksma, FCR, de la Oliva Valentín Muñoz, M, Wilson, N & van de Klundert, J 2019, 'Building Kidney Exchange Programmes in Europe: an overview of exchange practice and activities' Transplantation, vol. 103, nr. 7, blz. 1514-1522. DOI: 10.1097/TP.0000000000002432

Building Kidney Exchange Programmes in Europe : an overview of exchange practice and activities. / Biro, Peter (Corresponding author); Haase-Kromwijk, Bernadette; Andersson, Tommy ; Ásgeirsson, Eyolfur; Baltesová, Tatiana; Boletis, Ioannis; Bolotinha, Catarina; Bond, Gregor; Böhmig, Georg; Burnapp, Lisa; Cechlárová, Katarína; Di Caccio, Paolo; Fronek, Jiri; Hadaya, Karine; Hemke, Aline ; Jacquelinet, Christian; Johnson, Rachel; Kieszek, Rafal; Kuypers, Dirk; Leisman, Ruthanne; Macher, Marie-Alice; Manlove, David ; Menoudakou, Georgia; Salonen, Mikko; Smeulders, Bart; Sparacino, Vito; Spieksma, F.C.R.; de la Oliva Valentín Muñoz, Maria; Wilson, Nic; van de Klundert, Joris.

In: Transplantation, Vol. 103, Nr. 7, 01.07.2019, blz. 1514-1522.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

TY - JOUR

T1 - Building Kidney Exchange Programmes in Europe

T2 - Transplantation

AU - Biro,Peter

AU - Haase-Kromwijk,Bernadette

AU - Andersson,Tommy

AU - Ásgeirsson,Eyolfur

AU - Baltesová,Tatiana

AU - Boletis,Ioannis

AU - Bolotinha,Catarina

AU - Bond,Gregor

AU - Böhmig,Georg

AU - Burnapp,Lisa

AU - Cechlárová,Katarína

AU - Di Caccio,Paolo

AU - Fronek,Jiri

AU - Hadaya,Karine

AU - Hemke,Aline

AU - Jacquelinet,Christian

AU - Johnson,Rachel

AU - Kieszek,Rafal

AU - Kuypers,Dirk

AU - Leisman,Ruthanne

AU - Macher,Marie-Alice

AU - Manlove,David

AU - Menoudakou,Georgia

AU - Salonen,Mikko

AU - Smeulders,Bart

AU - Sparacino,Vito

AU - Spieksma,F.C.R.

AU - de la Oliva Valentín Muñoz,Maria

AU - Wilson,Nic

AU - van de Klundert,Joris

PY - 2019/7/1

Y1 - 2019/7/1

N2 - BACKGROUND:Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.METHODS:Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts.RESULTS:The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8% of their countries' living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe.CONCLUSIONS:Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

AB - BACKGROUND:Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.METHODS:Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts.RESULTS:The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8% of their countries' living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe.CONCLUSIONS:Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

U2 - 10.1097/TP.0000000000002432

DO - 10.1097/TP.0000000000002432

M3 - Article

VL - 103

SP - 1514

EP - 1522

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 7

ER -

Biro P, Haase-Kromwijk B, Andersson T, Ásgeirsson E, Baltesová T, Boletis I et al. Building Kidney Exchange Programmes in Europe: an overview of exchange practice and activities. Transplantation. 2019 jul 1;103(7):1514-1522. Beschikbaar vanaf, DOI: 10.1097/TP.0000000000002432