Breast cancer cells with distinct E-cadherin status exhibit different 3-D invasion behavior in a novel microfluidic system

H. Eslami Amirabadi, M. Tuerlings, S. SahebAli, R. Luttge, C.C. van Donkelaar, J. W.M. Martens, J.M.J. den Toonder

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

Different E-cadherin status in breast cancer is associated with different invasion abilities. However, a relevant in vitro study to study this is still missing from the literature. We developed a microfluidic system to characterize the invasion of three breast cancer cell lines with distinct E-cadherin status in 3D under the influence of a chemotactic gradient. We showed that this system can be used to capture the cells’ migration ability and invasion pattern. Using a perfusion system to control chemotactic gradients and integration of a 3D extracellular matrix, we could mimic two essential components of the tumor microenvironment during cancer invasion.

Originele taal-2Engels
Titel22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
UitgeverijChemical and Biological Microsystems Society
Pagina's1658-1660
Aantal pagina's3
Volume3
ISBN van elektronische versie9781510897571
StatusGepubliceerd - 1 jan 2018
Evenement22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duur: 11 nov 201815 nov 2018

Congres

Congres22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
LandTaiwan
StadKaohsiung
Periode11/11/1815/11/18

    Vingerafdruk

Citeer dit

Eslami Amirabadi, H., Tuerlings, M., SahebAli, S., Luttge, R., van Donkelaar, C. C., Martens, J. W. M., & den Toonder, J. M. J. (2018). Breast cancer cells with distinct E-cadherin status exhibit different 3-D invasion behavior in a novel microfluidic system. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (Vol. 3, blz. 1658-1660). Chemical and Biological Microsystems Society.