Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease

Dario Arnaldi, Sanne K. Meles, Alessandro Giuliani, Silvia Morbelli, Remco J. Renken, Annette Janzen, Elisabeth Sittig-Wiegand, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E. Reesink, Teus Van Laar, Laura K. Teune, Helmut Höffken, Marcus Luster, Lars Timmermann, Karl Kesper, Sofie M. Adriaanse, Jan Booij & 2 andere Gianmario Sambuceti, Nicola Girtler

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Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

TaalEngels
Pagina's229-239
Aantal pagina's11
TijdschriftJournal of Parkinson's Disease
Volume9
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 1 jan 2019

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    Arnaldi, D., Meles, S. K., Giuliani, A., Morbelli, S., Renken, R. J., Janzen, A., ... Girtler, N. (2019). Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. Journal of Parkinson's Disease, 9(1), 229-239. DOI: 10.3233/JPD-181468
    Arnaldi, Dario ; Meles, Sanne K. ; Giuliani, Alessandro ; Morbelli, Silvia ; Renken, Remco J. ; Janzen, Annette ; Sittig-Wiegand, Elisabeth ; Depboylu, Candan ; Reetz, Kathrin ; Overeem, Sebastiaan ; Pijpers, Angelique ; Reesink, Fransje E. ; Van Laar, Teus ; Teune, Laura K. ; Höffken, Helmut ; Luster, Marcus ; Timmermann, Lars ; Kesper, Karl ; Adriaanse, Sofie M. ; Booij, Jan ; Sambuceti, Gianmario ; Girtler, Nicola. / Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. In: Journal of Parkinson's Disease. 2019 ; Vol. 9, Nr. 1. blz. 229-239
    @article{b24ef24c48344a4399824a3bfef2378e,
    title = "Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease",
    abstract = "Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.",
    keywords = "F-FDG-PET, Parkinson's disease, REM sleep behavior disorder, synucleinopathy",
    author = "Dario Arnaldi and Meles, {Sanne K.} and Alessandro Giuliani and Silvia Morbelli and Renken, {Remco J.} and Annette Janzen and Elisabeth Sittig-Wiegand and Candan Depboylu and Kathrin Reetz and Sebastiaan Overeem and Angelique Pijpers and Reesink, {Fransje E.} and {Van Laar}, Teus and Teune, {Laura K.} and Helmut H{\"o}ffken and Marcus Luster and Lars Timmermann and Karl Kesper and Adriaanse, {Sofie M.} and Jan Booij and Gianmario Sambuceti and Nicola Girtler",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.3233/JPD-181468",
    language = "English",
    volume = "9",
    pages = "229--239",
    journal = "Journal of Parkinson's Disease",
    issn = "1877-7171",
    publisher = "IOS Press",
    number = "1",

    }

    Arnaldi, D, Meles, SK, Giuliani, A, Morbelli, S, Renken, RJ, Janzen, A, Sittig-Wiegand, E, Depboylu, C, Reetz, K, Overeem, S, Pijpers, A, Reesink, FE, Van Laar, T, Teune, LK, Höffken, H, Luster, M, Timmermann, L, Kesper, K, Adriaanse, SM, Booij, J, Sambuceti, G & Girtler, N 2019, 'Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease' Journal of Parkinson's Disease, vol. 9, nr. 1, blz. 229-239. DOI: 10.3233/JPD-181468

    Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. / Arnaldi, Dario; Meles, Sanne K.; Giuliani, Alessandro; Morbelli, Silvia; Renken, Remco J.; Janzen, Annette; Sittig-Wiegand, Elisabeth; Depboylu, Candan; Reetz, Kathrin; Overeem, Sebastiaan; Pijpers, Angelique; Reesink, Fransje E.; Van Laar, Teus; Teune, Laura K.; Höffken, Helmut; Luster, Marcus; Timmermann, Lars; Kesper, Karl; Adriaanse, Sofie M.; Booij, Jan; Sambuceti, Gianmario; Girtler, Nicola.

    In: Journal of Parkinson's Disease, Vol. 9, Nr. 1, 01.01.2019, blz. 229-239.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    TY - JOUR

    T1 - Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease

    AU - Arnaldi,Dario

    AU - Meles,Sanne K.

    AU - Giuliani,Alessandro

    AU - Morbelli,Silvia

    AU - Renken,Remco J.

    AU - Janzen,Annette

    AU - Sittig-Wiegand,Elisabeth

    AU - Depboylu,Candan

    AU - Reetz,Kathrin

    AU - Overeem,Sebastiaan

    AU - Pijpers,Angelique

    AU - Reesink,Fransje E.

    AU - Van Laar,Teus

    AU - Teune,Laura K.

    AU - Höffken,Helmut

    AU - Luster,Marcus

    AU - Timmermann,Lars

    AU - Kesper,Karl

    AU - Adriaanse,Sofie M.

    AU - Booij,Jan

    AU - Sambuceti,Gianmario

    AU - Girtler,Nicola

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

    AB - Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

    KW - F-FDG-PET

    KW - Parkinson's disease

    KW - REM sleep behavior disorder

    KW - synucleinopathy

    UR - http://www.scopus.com/inward/record.url?scp=85061206299&partnerID=8YFLogxK

    U2 - 10.3233/JPD-181468

    DO - 10.3233/JPD-181468

    M3 - Article

    VL - 9

    SP - 229

    EP - 239

    JO - Journal of Parkinson's Disease

    T2 - Journal of Parkinson's Disease

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    Arnaldi D, Meles SK, Giuliani A, Morbelli S, Renken RJ, Janzen A et al. Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. Journal of Parkinson's Disease. 2019 jan 1;9(1):229-239. Beschikbaar vanaf, DOI: 10.3233/JPD-181468