Bone mineralization after strontium and fluoride treatment in osteoporosis

E. Rokita, P.H.A. Mutsaers, J.A. Quaedackers, G. Tato, M.J.A. Voigt, de

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    The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and
    Originele taal-2Engels
    Pagina's (van-tot)412-417
    Aantal pagina's5
    TijdschriftNuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
    Nummer van het tijdschrift1-4
    StatusGepubliceerd - 1999

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