Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s

María J. Sánchez-Fernández, Manon Peerlings, Rosa P. Félix Lanao, Johan C.M.E. Bender, Jan C.M. van Hest, Sander C.G. Leeuwenburgh (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

6 Downloads (Pure)


To create a novel generation of barrier membranes with bone-adhesive properties, three-component membranes were successfully developed using a solvent-free approach by combining an occlusive polyester backing layer with a bone-adhesive fibrous gelatin carrier impregnated with calcium-binding alendronate-functionalized poly(2-oxazoline)s (POx-Ale). The mechanical properties of these novel membranes were similar to other commercially available barrier membranes. In contrast, the adhesion of our membranes towards bone was by far superior (i.e.62-fold) compared to conventional commercially available Bio-Gide® membranes. Moreover, alendronate-functionalized membranes retained their bone-adhesive properties under wet conditions in phosphate-buffered saline (PBS) solutions with and without collagenase. Finally, thein vitrodegradation of the membranes was studied by monitoring their weight loss upon immersion in PBS solutions with and without collagenase. The membranes degraded in a sustained manner, which was accelerated by the presence of collagenase due to enzymatic degradation of the carrier. In conclusion, our results show that surface functionalization of barrier membranes with alendronate moieties renders them adhesive to bone. As such, the biomaterials design strategy presented herein opens up new avenues of research on bone-adhesive membranes for guided bone regeneration.

Originele taal-2Engels
Pagina's (van-tot)5848-5860
Aantal pagina's13
TijdschriftJournal of Materials Chemistry B
Nummer van het tijdschrift29
StatusGepubliceerd - 7 aug 2021

Bibliografische nota

Publisher Copyright:
© The Royal Society of Chemistry 2021.


Duik in de onderzoeksthema's van 'Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s'. Samen vormen ze een unieke vingerafdruk.

Citeer dit