Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

A. de Vries, E.M.G. Custers, J. Lub, S. van den Bosch, K. Nicolay, H. Grüll

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

122 Citaten (Scopus)
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The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(butadiene)-b-poly(ethylene glycol) (PBD-PEO), as emulsifiers. The size, stability and cell viability was investigated for all stabilized emulsions. Three emulsions stabilized with either lipids or PBD-PEO were subsequently tested in vivo as a CT blood pool contrast agent in mice. While the lipid-stabilized emulsions turned out unstable in vivo, polymer-stabilized emulsions performed well in vivo. In blood, a contrast enhancement of 220 Hounsfield Units (HU) was measured directly after intravenous administration of 520 mg I/kg. The blood circulation half-life of a PBD-PEO stabilized emulsion was approximately 3 h and no noticeable in vivo toxicity was observed. These results show the potential of above emulsions for use as blood pool agents in contrast enhanced CT imaging.
Originele taal-2Engels
Pagina's (van-tot)6537-6544
Nummer van het tijdschrift25
StatusGepubliceerd - sep. 2010


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